Correlation Between the International Consensus Definition of the Cancer Anorexia-Cachexia Syndrome (CACS) and Patient-Centered Outcomes in Advanced Non-Small Cell Lung Cancer

Abstract Context The cancer anorexia-cachexia syndrome (CACS) is common in patients with advanced solid tumors and is associated with adverse outcomes including poor quality of life (QOL), impaired functioning, and shortened survival. Objectives To apply the recently posed weight-based international...

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Bibliographic Details
Published in:Journal of pain and symptom management 2015-04, Vol.49 (4), p.680-689
Main Authors: LeBlanc, Thomas W., MD, MA, Nipp, Ryan D., MD, Rushing, Christel N., MA, Samsa, Greg P., PhD, Locke, Susan C., PhD, Kamal, Arif H., MD, Cella, David F., PhD, Abernethy, Amy P., MD, PhD
Format: Article
Language:English
Subjects:
Aged
Anesthesia & Perioperative Care
Anorexia - diagnosis
Anorexia - physiopathology
Body Weight
Cachexia - diagnosis
Cachexia - physiopathology
carcinoma
Carcinoma, Non-Small-Cell Lung - diagnosis
Carcinoma, Non-Small-Cell Lung - physiopathology
Consensus
Female
health services research
Humans
Internationality
Karnofsky Performance Status
Longitudinal Studies
Male
Middle Aged
non-small cell lung
Pain Medicine
Patient Outcome Assessment
Prognosis
Quality of Life
Survival Analysis
Syndrome
Terminology as Topic
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Summary:Abstract Context The cancer anorexia-cachexia syndrome (CACS) is common in patients with advanced solid tumors and is associated with adverse outcomes including poor quality of life (QOL), impaired functioning, and shortened survival. Objectives To apply the recently posed weight-based international consensus CACS definition to a population of patients with advanced non-small cell lung cancer (NSCLC) and explore its impact on patient-reported outcomes. Methods Ninety-nine patients participated in up to four study visits over a six-month period. Longitudinal assessments included measures of physical function, QOL, and other clinical variables such as weight and survival. Results Patients meeting the consensus CACS criteria at Visit 1 had a significantly shorter median survival (239.5 vs. 446 days; hazard ratio, 2.06, P  
ISSN:0885-3924
1873-6513
DOI:10.1016/j.jpainsymman.2014.09.008