Cancer drug discovery by repurposing: teaching new tricks to old dogs

Highlights • Drug repurposing is the process of developing new indications for approved and abandoned drugs. • Approximately 90% of approved drugs possess secondary indications. • Cancer drug development through repurposing has less risk of failure. • Only a few non-cancer drugs (e.g., thalidomide)...

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Bibliographic Details
Published in:Trends in pharmacological sciences (Regular ed.) 2013-09, Vol.34 (9), p.508-517
Main Authors: Gupta, Subash C, Sung, Bokyung, Prasad, Sahdeo, Webb, Lauren J, Aggarwal, Bharat B
Format: Article
Language:English
Subjects:
Advanced Basic Science
Animals
Antineoplastic Agents - therapeutic use
cancer drugs
Drug Discovery
drug repurposing
Humans
inflammation
Neoplasms - drug therapy
NF-κB
STAT3
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Summary:Highlights • Drug repurposing is the process of developing new indications for approved and abandoned drugs. • Approximately 90% of approved drugs possess secondary indications. • Cancer drug development through repurposing has less risk of failure. • Only a few non-cancer drugs (e.g., thalidomide) have progressed straight to cancer patients. • The hurdles associated with expensive Phase II and III clinical trials have not changed over the years.
ISSN:0165-6147
1873-3735
DOI:10.1016/j.tips.2013.06.005