Attractive action of FGF-signaling contributes to the postnatal developing hippocampus

• Published in: Hippocampus 2015-04, Vol.25 (4), p.486-499
• Main Authors: Cuccioli, V., Bueno, C., Belvindrah, R., Lledo, P.-M., Martinez, S.
• Format: Article
• Language: English
• Subjects: Animals; Animals, Newborn; Cell Differentiation; Cell Movement - physiology; Cerebral Ventricles - cytology; Coculture Techniques; dentate gyrus; Embryo, Mammalian; Fibroblast Growth Factors - metabolism; Gene Expression Regulation, Developmental - physiology; Hippocampus - cytology; Hippocampus - growth & development; Hippocampus - surgery; Hippocampus - transplantation; In Vitro Techniques; Mice; Mice, Inbred ICR; Mice, Transgenic; Nerve Tissue Proteins - genetics; Nerve Tissue Proteins - metabolism; Neurogenesis; neuronal migration; Neurons - physiology; Organ Culture Techniques; plasticity; Signal Transduction - physiology; signaling molecules; Stem Cell Transplantation; Transduction, Genetic
• ISSN: 1050-9631; 1098-1063
• DOI: 10.1002/hipo.22386

ABSTRACT During brain development neural cell migration is a crucial, well‐orchestrated, process, which leads to the proper whole brain structural organization. As development proceeds, new neurons are continuously produced, and this protracted neurogenesis is maintained throughout life in specialized germinative areas inside the telencephalon: the subventricular zone (SVZ) and the dentate gyrus (DG) of the hippocampus. In the anterior SVZ, newly generated neurons migrate through long distances, along the rostral migratory stream (RMS), before reaching their final destinations in the olfactory bulb (OB). Intriguingly, recent observations pointed out the existence of other postnatal tangential routes of migration alternative to the RMS but still starting from the SVZ. The presence of such dynamic and heterogeneous cell movements contributes to important features in the postnatal brain such as neural cell replacement and plasticity in cortical regions. In this work, we asked whether a caudal migratory pathway starting from the caudal SVZ continues through life. Strikingly, in vivo analysis of this caudal migration revealed the presence of a postnatal contribution of SVZ to the hippocampus. In vitro studies of the caudal migratory stream revealed the role of FGF signaling in attracting caudally the migrating neuroblasts during postnatal stages. Our findings demonstrate a postnatal neuronal contribution from the caudal ganglionic eminence (CGE) CGE‐SVZ to the hippocampus through an FGF‐dependent migrating mechanism. All together our data emphasizes the emerging idea that a developmental program is still operating in discrete domains of the postnatal brain and may contribute to the regulation of neural cell replacement processes in physiological plasticity and/or pathological circumstances. © 2014 Wiley Periodicals, Inc.