DNMT1 and EZH2 mediated methylation silences the microRNA-200b/a/429 gene and promotes tumor progression

•EZH2 regulates the tri-methylation of H3K27 and reduces DNMT1 expression.•Knocking-down of DNMT1 down-regulates the components of the PRC2 (EZH2, SUZ12, EED) complex.•EZH2 and DNMT1 inactivate the expression of mir-200b/a/429 cluster. Aberrant expression of the microRNA-200 (miR-200) family has bee...

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Bibliographic Details
Published in:	Cancer letters 2015-04, Vol.359 (2), p.198-205
Main Authors:	Ning, Xianghong, Shi, Zhendong, Liu, Xi, Zhang, Anling, Han, Lei, Jiang, Kui, Kang, Chunsheng, Zhang, Qingyu
Format:	Article
Language:	English
Subjects:	Adenosine - analogs & derivatives Adenosine - pharmacology Animals Antineoplastic Agents - pharmacology Azacitidine - analogs & derivatives Azacitidine - pharmacology Cell Line, Tumor Chromatin Deoxyribonucleic acid Disease Progression DNA DNA (Cytosine-5-)-Methyltransferase 1 DNA (Cytosine-5-)-Methyltransferases - antagonists & inhibitors DNA (Cytosine-5-)-Methyltransferases - physiology DNA Methylation DNMT Enhancer of Zeste Homolog 2 Protein Epigenetics Experiments EZH2 Gastric cancer Gene expression Gene Expression Regulation, Neoplastic Gene Silencing Glioblastoma - therapy Hematology, Oncology and Palliative Medicine Histone modifications Histones - metabolism Humans Medical prognosis Mice, Inbred BALB C Mice, Nude MicroRNAs - genetics MicroRNAs - metabolism miR-200 Polycomb Repressive Complex 2 - antagonists & inhibitors Polycomb Repressive Complex 2 - physiology Proteins RNA polymerase Stomach Neoplasms - therapy Tumor Burden Tumors Xenograft Model Antitumor Assays
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