Stereometabolism of ethylbenzene in man : gas chromatographic determination of urinary excreted mandelic acid enantiomers and phenylglyoxylic acid and their relation to the height of occupational exposure

Ethylbenzene is an important industrial solvent and a key substance in styrene production. Ethylbenzene metabolism leads to the formation of mandelic acid, which occurs in two enantiomeric forms, and phenylglyoxylic acid. To decide which enantiomer is preferably formed, 70 urine samples of exposed w...

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Bibliographic Details
Published in:International archives of occupational and environmental health 1992-08, Vol.64 (2), p.75-78
Main Authors: KORN, M, GFÖRER, W, HERZ, R, WODARZ, I, WODARZ, R
Format: Article
Language:English
Subjects:
Benzene Derivatives - metabolism
Biological and medical sciences
Chemical and industrial products toxicology. Toxic occupational diseases
Chemical Industry
Chromatography, Gas
Glyoxylates - urine
Humans
Mandelic Acids - chemistry
Mandelic Acids - urine
Medical sciences
Occupational Exposure - analysis
Paint
Solvents
Solvents - metabolism
Stereoisomerism
Toxicology
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Summary:Ethylbenzene is an important industrial solvent and a key substance in styrene production. Ethylbenzene metabolism leads to the formation of mandelic acid, which occurs in two enantiomeric forms, and phenylglyoxylic acid. To decide which enantiomer is preferably formed, 70 urine samples of exposed workers were taken at the end of shifts and--after 3-pentyl ester derivatisation--gas chromatographically analysed. The R/S ratio of mandelic acid enantiomers in urine amounts to 19:1, which means that R-mandelic acid is a major metabolite and S-mandelic acid is one of the minor urinary metabolites of ethylbenzene in man. The R/S ratio is independent of ambient air concentration of ethylbenzene within the investigated range. Compared to an ethylbenzene monoexposure the height of total mandelic acid excretion is decreased in the case of coexposure to other aromatic solvents.
ISSN:0340-0131
1432-1246
DOI:10.1007/BF00381472