Radiation-grafting of acrylamide onto silicone rubber films for diclofenac delivery

This work focuses on the pre-irradiation grafting of acrylamide (AAm) onto silicone rubber films (SR) and evaluates the effect of gamma-ray radiation conditions on the grafting yield, which in turn may influence the performance of the grafted materials as components of drug-eluting devices. Pristine...

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Bibliographic Details
Published in:Radiation physics and chemistry (Oxford, England : 1993) England : 1993), 2015-02, Vol.107, p.164-170
Main Authors: Magaña, Hector, Palomino, Kenia, Cornejo-Bravo, Jose M., Alvarez- Lorenzo, Carmen, Concheiro, Angel, Bucio, Emilio
Format: Article
Language:English
Subjects:
Acrylamide
Bioinspired interaction
Cytocompatible polymers
Diclofenac
Diclofenac release
Differential scanning calorimetry
Drugs
Fibroblasts
Grafting
Polymer grafting
Silicone rubber
Swelling
Uptakes
γ-irradiation
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Summary:This work focuses on the pre-irradiation grafting of acrylamide (AAm) onto silicone rubber films (SR) and evaluates the effect of gamma-ray radiation conditions on the grafting yield, which in turn may influence the performance of the grafted materials as components of drug-eluting devices. Pristine and modified SR were characterized using FTIR-ATR, DSC, TGA, swelling, and water contact angle analysis in order to elucidate the effects of AAm grafting onto SR. Grafted films with content in AAm ranging from 0.81% to 22.20% showed excellent cytocompatibility against fibroblasts, and capability to uptake the anti-inflammatory drug diclofenac. Amount of drug loaded directly correlated with the grafting degree of the films. Drug release studies were performed at pH 7.4 and 37°C (physiological conditions). Most grafted films released the drug in a sustained way for at least three hours. [Display omitted] •SR–g-AAm depends on dose, monomer concentration, and reaction time and temperature.•Diclofenac sodium salt is loaded and released in a sustained way from SR–g-AAm films.•SR–g-AAm films are cytocompatible and have potential as components of drug–device.
ISSN:0969-806X
1879-0895
DOI:10.1016/j.radphyschem.2014.10.011