Formation of Diazepam–Lanthanides(III) Complexes in the 50–50 Volume % Ethanol–Water Solvent System and Study of the Effect of Temperature on the Complex Formation Constants

Diazepam (7-chloro-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one) is an important derivative of the 1,4-benzodiazepine compound commercially distributed as Valium. The complex formation constants of diazepam with some light lanthanide(III) metal ions have been studied by potentiometric me...

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Bibliographic Details
Published in:Journal of solution chemistry 2012-03, Vol.41 (2), p.241-248
Main Authors: Bayes, Gunaji S., Raut, Sambhaji S., Patil, Vishwanath R., Lokhande, Rama S.
Format: Article
Language:English
Subjects:
Chemistry
Chemistry and Materials Science
Complex formation
Condensed Matter Physics
Constants
Derivatives
Exact sciences and technology
General and physical chemistry
Geochemistry
Industrial Chemistry/Chemical Engineering
Inorganic Chemistry
Metal ions
Oceanography
Physical Chemistry
Protonation
Solutions
Solvents
Strength
Titration
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Summary:Diazepam (7-chloro-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one) is an important derivative of the 1,4-benzodiazepine compound commercially distributed as Valium. The complex formation constants of diazepam with some light lanthanide(III) metal ions have been studied by potentiometric measurements. All titrations were performed in 50–50% (volume/volume) ethanol–water solvent mixtures at constant ionic strength (0.10 mol⋅dm −3 ). The ionic strength was maintained by using sodium perchlorate. The complex formation constants were determined at 25.00, 35.00 and 45.00 °C. With increasing temperature, a decrease was observed in the protonation constant (p K ) of diazepam.
ISSN:0095-9782
1572-8927
DOI:10.1007/s10953-012-9798-3