Stochastic synchronization of interacting pathways in testosterone model

• Published in: Computational biology and chemistry 2012-12, Vol.41, p.10-17
• Main Authors: Alam, Md. Jahoor, Devi, Gurumayum Reenaroy, Singh, R.K. Brojen, Ramaswamy, R., Thakur, Sonu Chand, Sharma, B. Indrajit
• Format: Article
• Language: English
• Subjects: Algorithms; Cell signaling; Computer simulation; Constants; Coupling; Intercellular communication; Intracellular communication; Joining; Models, Biological; Oscillators; Pathways; Stochastic Processes; Stochasticity; Synchronism; Synchronization; Testosterone - chemistry; Testosterone - metabolism; Thermodynamics
• ISSN: 1476-9271; 1476-928X
• DOI: 10.1016/j.compbiolchem.2012.08.001

[Display omitted] ► The possible coupling mechanism in the interacting pathways of testosterone hormone is studied theoretically. ► We found coupling constant to follow power law behavior with system size showing the effect of noise in it. ► The destructive role of noise at small system size is seen giving hindrance to synchronization. ► Delay induced synchronization of the interacting pathways is identified in this model. We examine the possibilities of various coupling mechanisms among a group of identical stochastic oscillators via Chemical Langevin formalism where each oscillator is modeled by stochastic model of testosterone (T) releasing pathway. Our results show that the rate of synchrony among the coupled oscillators depends on various parameters namely fluctuating factor, coupling constants ϵ, and interestingly on system size. The results show that synchronization is achieved much faster in classical deterministic system rather than stochastic system. Then we do large scale simulation of such coupled pathways using stochastic simulation algorithm and the detection of synchrony is measured by various order parameters such as synchronization manifolds, phase plots etc and found that the proper synchrony of the oscillators is maintained in different coupling mechanisms and support our theoretical claims. We also found that the coupling constant follows power law behavior with the systems size (V) by ϵ∼AV−γ, where γ=1 and A is a constant. We also examine the phase transition like behavior in all coupling mechanisms that we have considered for simulation. The behavior of the system is also investigated at thermodynamic limit; where V→∞, molecular population, N→∞ but NV→finite, to see the role of noise in information processing and found the destructive role in the rate of synchronization.