Favorable prognosis of biallelic CEBPA gene mutations in acute myeloid leukemia patients: a meta-analysis

Objectives Increasing number of studies suggested that biallelic CEBPA (bi CEBPA) mutations were associated with favorable prognosis in patients with acute myeloid leukemia (AML), but the results remain inconclusive. We therefore present a meta‐analysis to evaluate the prognostic value of bi CEBPA m...

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Published in:European journal of haematology 2015-05, Vol.94 (5), p.439-448
Main Authors: Li, Hong-Ying, Deng, Dong-Hong, Huang, Ying, Ye, Fang-Hui, Huang, Lu-Lu, Xiao, Qiang, Zhang, Bing, Ye, Bing-Bing, Lai, Yong-Rong, Mo, Zeng-Nan, Liu, Zhen-Fang
Format: Article
Language:English
Subjects:
Acute myeloid leukemia
Alleles
biallelic CEBPA mutations
CCAAT-Enhancer-Binding Proteins - genetics
Female
Gene Expression
Humans
Leukemia, Myeloid, Acute - diagnosis
Leukemia, Myeloid, Acute - genetics
Leukemia, Myeloid, Acute - pathology
Male
meta-analysis
Mutation
Prognosis
Survival Analysis
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Summary:Objectives Increasing number of studies suggested that biallelic CEBPA (bi CEBPA) mutations were associated with favorable prognosis in patients with acute myeloid leukemia (AML), but the results remain inconclusive. We therefore present a meta‐analysis to evaluate the prognostic value of bi CEBPA mutations in patients with AML. Methods A comprehensive literature search was undertaken through August 2014 looking for eligible studies. Pooled hazard ratios (HRs) estimates and 95% confidence intervals (95% CIs) in overall survival (OS) and event‐free survival (EFS) were used to calculate estimated effect. Results Ten studies covering a total of 6219 subjects were included in this analysis. Overall, bi CEBPA mutations were associated with favorable clinical outcome in patients with AML (HR for EFS: 0.41, 95% CI: 0.32–0.52; for OS: 0.37, 95% CI: 0.27–0.50), in cytogenetically normal (CN)‐AML (HR for EFS: 0.38, 95% CI: 0.29–0.49; for OS: 0.32, 95% CI: 0.23–0.43). When took the cohort of monoallelic CEBPA (mo CEBPA) mutated and wild‐type CEBPA (wt CEBPA) AML as a reference group, bi CEBPA mutated AML also shown beneficial outcomes (HR for OS: 0.52, 95% CI: 0.37–0.72). No significant difference was found between mo CEBPA mutation and wt CEBPA in patients with AML or CN‐AML (P > 0.05). Conclusion Bi CEBPA mutations in patients with AML are strongly associated with a favorable prognosis, which suggested that bi CEBPA mutations would potentially serve as a novel prognostic marker in AML.
ISSN:0902-4441
1600-0609
DOI:10.1111/ejh.12450