Candidate-gene association study searching for genetic factors involved in migraine chronification

Introduction Chronic migraine (CM) is at the severe end of the clinical migraine spectrum, but its genetic background is unknown. Our study searched for evidence that genetic factors are involved in the chronification process. Methods We initially selected 144 single-nucleotide polymorphisms (SNPs)...

Full description

Saved in:
Bibliographic Details
Published in:Cephalalgia 2015-05, Vol.35 (6), p.500-507
Main Authors: Louter, MA, Fernandez-Morales, J, de Vries, B, Winsvold, B, Anttila, V, Fernandez-Cadenas, I, Vila-Pueyo, M, Sintas, C, van Duijn, CM, Cormand, B, Álvarez-Sabin, J, Montaner, J, Ferrari, MD, van den Maagdenberg, AMJM, Palotie, A, Zwart, JA, Macaya, A, Terwindt, GM, Pozo-Rosich, P
Format: Article
Language:English
Subjects:
Chronic Disease
Female
Genetic Association Studies
Genetic Predisposition to Disease - genetics
Humans
Male
Middle Aged
Migraine Disorders - genetics
Polymorphism, Single Nucleotide
Citations: Items that this one cites
Items that cite this one
Online Access:Request full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Introduction Chronic migraine (CM) is at the severe end of the clinical migraine spectrum, but its genetic background is unknown. Our study searched for evidence that genetic factors are involved in the chronification process. Methods We initially selected 144 single-nucleotide polymorphisms (SNPs) from 48 candidate genes, which we tested for association in two stages: The first stage encompassed 262 CM patients, the second investigated 226 patients with high-frequency migraine (HFM). Subsequently, SNPs with p values 
ISSN:0333-1024
1468-2982
DOI:10.1177/0333102414547141