Visceral mesh modified with cyclodextrin for the local sustained delivery of ropivacaine

[Display omitted] The aim of the study was to develop a polyester visceral implant modified with a cyclodextrin polymer for the local and prolonged delivery of ropivacaine to reduce post operatory pain. Therefore, we applied a coating of an inguinal mesh with a crosslinked polymer of hydroxypropyl-β...

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Bibliographic Details
Published in:International journal of pharmaceutics 2014-12, Vol.476 (1-2), p.149-159
Main Authors: Vermet, G., Degoutin, S., Chai, F., Maton, M., Bria, M., Danel, C., Hildebrand, H.F., Blanchemain, N., Martel, B.
Format: Article
Language:English
Subjects:
2-Hydroxypropyl-beta-cyclodextrin
Adsorption
Amides - administration & dosage
Amides - chemistry
Anesthetics, Local - administration & dosage
Anesthetics, Local - chemistry
Animals
beta-Cyclodextrins - chemistry
Cells, Cultured
Cyclodextrin
Delayed-Action Preparations
Drug Delivery Systems
Drug Implants
Excipients - chemistry
Local anesthetic
Magnetic Resonance Spectroscopy
Mice
NIH 3T3 Cells
Pain, Postoperative - prevention & control
Polyesters - chemistry
Prolonged delivery
Ropivacaine
Surface modification
Time Factors
Visceral mesh textile
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Summary:[Display omitted] The aim of the study was to develop a polyester visceral implant modified with a cyclodextrin polymer for the local and prolonged delivery of ropivacaine to reduce post operatory pain. Therefore, we applied a coating of an inguinal mesh with a crosslinked polymer of hydroxypropyl-β-cyclodextrin (HPβCD) whose specific host–guest complex forming properties were expected to improve the adsorption capacity of the implant toward anesthetic, and then to release it within a sustained period. The modification reaction of the textile with cyclodextrin was explored through the study of the influence of the pad/dry/cure process parameters and the resulting implant (PET–CD) was characterized by solid state NMR and SEM. Besides, the inclusion complex between ropivacaine and CD was studied by NMR and capillary electrophoresis in PBS medium. Finally, ropivacaine sorption test showed that a maximum of 30mg/g of ropivacaine could be adsorbed on the functionalized samples. In dynamic batch tests in PBS at pH 7.4, the release could be observed up to 6h. The cytocompatibility of the PET–CD loaded with ropivacaine was also studied and reached 65% cell vitality after 6 days.
ISSN:0378-5173
1873-3476
DOI:10.1016/j.ijpharm.2014.09.042