A predictor of small-for-gestational-age infant: oral glucose challenge test

• Published in: Irish journal of medical science 2015-06, Vol.184 (2), p.285-289
• Main Authors: Cekmez, Y., Ozkaya, E., Öcal, F. D., Süer, N., Küçüközkan, T.
• Format: Article
• Language: English
• Subjects: Adult; Birth Weight; Blood Glucose - analysis; Family Medicine; Fasting - blood; Female; General Practice; Gestational Age; Glucose Tolerance Test; Humans; Infant, Newborn; Infant, Small for Gestational Age; Internal Medicine; Male; Medicine; Medicine & Public Health; Original Article; Predictive Value of Tests; Pregnancy; Sensitivity and Specificity; Young Adult
• ISSN: 0021-1265; 1863-4362
• DOI: 10.1007/s11845-014-1101-8

Objective This study was performed to investigate the role of first-hour 50-g oral glucose challenge test (GCT) parameters in predicting the risk of delivering a small-for-gestational-age infant and to determine the accuracy of estimated fetal weight. Methods We screened 2,643 pregnant women >20 years of age and excluded 552 patients according to exclusion criteria. Newborns were assigned to three groups as SGA( n :100), AGA( n :100), and LGA( n :100) according to birth weight. All mothers received 50-g GCT in their 24–28th weeks of gestation. We examined the relationship between birthweight and test results. Results First-hour serum glucose level after the test significantly predicted babies with small for gestational age. Optimal cutoff value was obtained at a level of 74.5 mg/dl with 67 % sensitivity and 55 % specificity. The estimated fetal weight of Hadlock 5 formula was strongly correlated with the birth weight (Pearson r  = 0.89). Conclusion Our study revealed that 50-g oral glucose challenge test may predict small-for-gestational-age cases with 67 % sensitivity, and our data revealed that there is a significant correlation between estimated fetal weight of Hadlock 5 formula and the birth weight.