The influence of low-level laser therapy with alendronate irrigation on healing of bone defects in rats

The aim of this study was to investigate the effects of alendronate (Aln) irrigation with low-level laser therapy (LLLT) on the healing of bone defects in rats. Sixty Wistar rats weighing 250 to 300 g were randomly divided into three groups of 20 animals each: (1) control group, (2) Aln group, and (...

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Bibliographic Details
Published in:Lasers in medical science 2015-04, Vol.30 (3), p.1141-1146
Main Authors: Akyol, Utkan Kamil, Sipal, Sare, Demirci, Elif, Gungormus, Metin
Format: Article
Language:English
Subjects:
Alendronate - administration & dosage
Aluminum nitride
Animals
Bone Density Conservation Agents - administration & dosage
Bone Regeneration - drug effects
Bone Regeneration - radiation effects
Bones
Chemoradiotherapy
Defects
Dentistry
Femur - drug effects
Femur - pathology
Femur - radiation effects
Healing
Irrigation
Lasers
Lasers, Semiconductor - therapeutic use
Low-Level Light Therapy
Medical research
Medicine
Medicine & Public Health
Optical Devices
Optics
Original Article
Osteogenesis
Photonics
Quantum Optics
Rats
Rats, Wistar
Therapeutic Irrigation
Therapy
Wound Healing
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Summary:The aim of this study was to investigate the effects of alendronate (Aln) irrigation with low-level laser therapy (LLLT) on the healing of bone defects in rats. Sixty Wistar rats weighing 250 to 300 g were randomly divided into three groups of 20 animals each: (1) control group, (2) Aln group, and (3) Aln with LLLT group. The distal epiphysis of all rats was perforated with a surgical bone drill. Twenty rats served as control. The bone defects of 40 rats received local alendronate sodium trihydrate irrigation (1 mg/ml) at the time of surgery. LLLT was applied to the bone defects of 20 rats immediately after Aln irrigation, and repeated on days 2, 4, 6, and 8 with a total dose of 10 J/cm 2 (2 J/cm 2  × 5). Continuous wave of GaAlAs laser (808 nm) was used with a power density of 0.1 W/cm 2 . Laser energy was applied for 20 s (0.1 W × 20 s/1 cm 2 ) per session. Control group, Aln group, and Aln with LLLT group rats were sacrificed at days 10 and 20 to compare the bone healing of each group histologically. There were significant differences between the three groups regarding union, substantia spongiosa, cortex formation, and in sum of histologic scores on days 10 and 20 ( P  
ISSN:0268-8921
1435-604X
DOI:10.1007/s10103-015-1720-y