Preparation and evaluation of PEO-coated materials for a microchannel hemodialyzer

The marked increase in surface-to-volume ratio associated with microscale devices for hemodialysis leads to problems with hemocompatibility and blood flow distribution that are more challenging to manage than those encountered at the conventional scale. In this work stable surface modifications with...

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Bibliographic Details
Published in:Journal of biomedical materials research. Part B, Applied biomaterials Applied biomaterials, 2014-07, Vol.102 (5), p.1014-1020
Main Authors: Heintz, Keely, Schilke, Karl F., Snider, Joshua, Lee, Woo-Kul, Truong, Mitchell, Coblyn, Matthew, Jovanovic, Goran, McGuire, Joseph
Format: Article
Language:English
Subjects:
Biological and medical sciences
Biomedical materials
Blood flow
Coated Materials, Biocompatible - chemistry
Devices
Dimethylpolysiloxanes - chemistry
Kidneys, Artificial
Materials research
Materials science
Medical sciences
Microchannels
PEO-polybutadiene-PEO triblock polymer
polyacrylonitrile membrane
Polyacrylonitriles
polycarbonate
Polycarbonates
Polycarboxylate Cement - chemistry
Polyethylene Glycols
protein repulsion
Silicone resins
Surface chemistry
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Surgical implants
Technology. Biomaterials. Equipments
urea permeability
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Summary:The marked increase in surface-to-volume ratio associated with microscale devices for hemodialysis leads to problems with hemocompatibility and blood flow distribution that are more challenging to manage than those encountered at the conventional scale. In this work stable surface modifications with pendant polyethylene oxide (PEO) chains were produced on polydimethylsiloxane (PDMS), polycarbonate microchannel, and polyacrylonitrile membrane materials used in construction of microchannel hemodialyzer test articles. PEO layers were prepared by radiolytic grafting of PEO-polybutadiene-PEO (PEO-PB-PEO) triblock polymers to the material surfaces. Protein repulsion was evaluated by measurement of surface-bound enzyme activity following contact of uncoated and PEO-coated surfaces with β-galactosidase. Protein adsorption was decreased on PEO-coated polycarbonate and PDMS materials to about 20% of the level recorded on the uncoated materials. Neither the triblocks nor the irradiation process was observed to have any effect on protein interaction with the polyacrylonitrile membrane, or its permeability to urea. This approach holds promise as a means for in situ application of safe, efficacious coatings to microfluidic devices for blood processing that will ensure good hemocompatibility and blood flow distribution, with no adverse effects on mass transfer.
ISSN:1552-4973
1552-4981
DOI:10.1002/jbm.b.33082