Hyaluronic acid colloidal gels as self-assembling elastic biomaterials

Hyaluronic acid (HA) is a naturally occurring biodegradable polymer with a variety of applications in medicine. The use of HA as a filler or scaffold for regenerating tissues often requires improving the elastic properties of HA. This is conventionally accomplished via chemical crosslinking, which m...

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Bibliographic Details
Published in:Journal of biomedical materials research. Part B, Applied biomaterials Applied biomaterials, 2014-04, Vol.102 (3), p.612-618
Main Authors: Fakhari, Amir, Phan, Quang, Berkland, Cory
Format: Article
Language:English
Subjects:
Algorithms
Biocompatible Materials - chemistry
Biological and medical sciences
Biomedical materials
colloidal gel
Colloids
Colloids - chemistry
Cross-Linking Reagents
Crosslinking
Elasticity
Failure
Gels
hyaluronic acid
Hyaluronic Acid - chemistry
Hydroxyapatite
Materials research
Materials science
Mechanical Phenomena
Medical sciences
Molecular Weight
nanoparticle
Nanoparticles
Particle Size
Shear Strength
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Surgical implants
Technology. Biomaterials. Equipments
Three dimensional
Viscosity
Water - chemistry
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Summary:Hyaluronic acid (HA) is a naturally occurring biodegradable polymer with a variety of applications in medicine. The use of HA as a filler or scaffold for regenerating tissues often requires improving the elastic properties of HA. This is conventionally accomplished via chemical crosslinking, which might require the generation of toxic free radicals. Although the mechanical properties of the resulting gel material can be tuned, these types of materials are static and susceptible to mechanical failure. The aim of this study was to develop a colloidal system for scaffold fabrication that is held together by physical interactions between HA nanoparticles. HA nanoparticles composed of 17 kDa HA suspended in water at different concentrations (15%, 30%, and 45% w/v, respectively) formed a stable three-dimensional (3D) colloidal gel as a result of physical entanglement of free polymer chains on the surfaces of nanoparticles. The swelling ratio, shear moduli (G), compressive failure properties, and viscosity of colloidal gels were concentration dependent. The colloidal gels also were found to exhibit dynamic and recoverable properties, thus suggesting that these "self-associating colloids" offer characteristics distinct arising from crosslinked polymers or high concentration colloids.
ISSN:1552-4973
1552-4981
DOI:10.1002/jbm.b.33041