Novel self-assembly-induced 3D plotting for macro/nano-porous collagen scaffolds comprised of nanofibrous collagen filaments

This study proposes self-assembly-induced 3D plotting as an innovative solid freeform fabrication (SFF) technique for the production of macro/nano-porous collagen scaffolds, particularly comprised of nanofibrous collagen filaments. In this technique, collagen filaments deposited in a coagulation bat...

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Bibliographic Details
Published in:Materials letters 2015-03, Vol.143, p.265-268
Main Authors: Shin, Kwan-Ha, Kim, Jong-Woo, Koh, Young-Hag, Kim, Hyoun-Ee
Format: Article
Language:English
Subjects:
Biomaterials
Biomimetic
Collagens
Deposition
Filaments
Microstructure
Nanostructure
Plotting
Polymers
Porosity
Porous materials
Scaffolds
Self assembly
Three dimensional
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Summary:This study proposes self-assembly-induced 3D plotting as an innovative solid freeform fabrication (SFF) technique for the production of macro/nano-porous collagen scaffolds, particularly comprised of nanofibrous collagen filaments. In this technique, collagen filaments deposited in a coagulation bath could be effectively gelled through the self-assembly of collagen molecules into fibrils, accordingly, enabling the 3-dimensional deposition of collagen filaments with a collagen nanofiber network. The unique macro/nano-structure could be structurally stabilized by dehydration process coupled with chemical cross-linking. The porous collagen scaffolds produced had 3-dimensionally interconnected macropores (~ 451×305μm in pore width) separated by nanoprous collagen filaments. In addition, the macro/nano-porous collagen scaffolds showed the tensile strength of~353kPa and compressive strength of~31kPa at a porosity of~95vol% and excellent in vitro biocompatibility, assessed using pre-osteoblast MC3T3-E1 cells. •Self-assembly-induced 3D plotting was developed as an innovative SFF technique•Collagen scaffolds with a unique macro/nano-porous structure were produced.•Nanofibrous collagen filaments could be created through self-assembly of collagen.•The scaffolds had reasonable mechanical properties and excellent biocompatibility.
ISSN:0167-577X
1873-4979
DOI:10.1016/j.matlet.2014.12.119