Oral aspects in celiac disease children: clinical and dental enamel chemical evaluation

Objective The aim of this study was to evaluate the oral manifestations of celiac disease (CD), the chemical composition of dental enamel, and the occurrence of CD in children with dental enamel defects (DEDs). Study Design In the study, 52 children with CD and 52 controls were examined for DEDs, re...

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Published in:Oral surgery, oral medicine, oral pathology and oral radiology oral medicine, oral pathology and oral radiology, 2015-06, Vol.119 (6), p.636-643
Main Authors: de Carvalho, Fabrício Kitazono, PhD, de Queiroz, Alexandra Mussolino, PhD, Bezerra da Silva, Raquel Assed, PhD, Sawamura, Regina, PhD, Bachmann, Luciano, PhD, Bezerra da Silva, Léa Assed, PhD, Nelson-Filho, Paulo, PhD
Format: Article
Language:English
Subjects:
Adolescent
Case-Control Studies
Celiac Disease - complications
Child
Child, Preschool
Dental Caries - etiology
Dental Enamel - chemistry
Dentistry
Humans
Infant
Microscopy, Electron, Scanning
Molar
Saliva - chemistry
Salivation
Spectrometry, X-Ray Emission
Stomatitis, Aphthous - etiology
Surgery
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Summary:Objective The aim of this study was to evaluate the oral manifestations of celiac disease (CD), the chemical composition of dental enamel, and the occurrence of CD in children with dental enamel defects (DEDs). Study Design In the study, 52 children with CD and 52 controls were examined for DEDs, recurrent aphthous stomatitis (RAS), dental caries experience, and salivary parameters. In addition, 10 exfoliated primary enamel molars from each group were analyzed by energy dispersive x-ray spectroscopy and Fourier transform infrared spectroscopy. Fifty children with DEDs were submitted to CD diagnosis. Results Among the children with CD, a higher prevalence of DEDs ( P  = .00001) and RAS ( P  = .0052), lower caries experience ( P  = .0024), and reduction of salivary flow ( P  = .0060) were observed. Dental enamel from the children with CD demonstrated a lower calcium-to-phosphorus ratio ( P  = .0136), but no difference in the carbonate-to-phosphate ratio ( P  = .5862) was observed. In the multivariate analysis, CD was a protective factor for caries (OR = 0.74) and a risk factor for RAS (OR3.23). Conclusions The children with CD presented with more RAS, DEDs, reduction of salivary flow, and chemical alterations in the enamel.
ISSN:2212-4403
2212-4411
DOI:10.1016/j.oooo.2015.02.483