Perioperative blood product administration and thromboembolic events in patients with treated polycythemia vera: a case-control study

BACKGROUND Patients with polycythemia vera (PV) have historically been considered to be at high risk for perioperative hemorrhagic and thromboembolic complications. However, no recent studies have compared these outcomes between treated PV patients and patients without PV undergoing similar procedur...

Full description

Saved in:
Bibliographic Details
Published in:Transfusion (Philadelphia, Pa.) Pa.), 2015-05, Vol.55 (5), p.1090-1097
Main Authors: Weingarten, Toby N., Hofer, Ryan E., Ahle, Barrett J., Kemp, Keri M., Nkwonta, Jacinta A., Narr, Bradly J., Pardanani, Animesh, Schroeder, Darrell R., Sprung, Juraj
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Blood products
Case-Control Studies
Confidence intervals
Female
Health risk assessment
Humans
Male
Middle Aged
Polycythemia Vera - surgery
Polycythemia Vera - therapy
Retrospective Studies
Thromboembolism - etiology
Transfusion Reaction
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:BACKGROUND Patients with polycythemia vera (PV) have historically been considered to be at high risk for perioperative hemorrhagic and thromboembolic complications. However, no recent studies have compared these outcomes between treated PV patients and patients without PV undergoing similar procedures. STUDY DESIGN AND METHODS Patients with PV who underwent surgery with anesthesia from June 1, 2006, to May 31, 2011, were randomly matched (sex, age, type of surgical procedure, surgical year) at a ratio of 1:4 with control patients without PV. Conditional logistic regression analysis adjusting for surgical duration, preoperative hemoglobin, platelet count, and cardiovascular disease was used to assess the association between PV and blood product transfusions, thromboembolism, and other major cardiovascular and pulmonary complications. RESULTS Fifty‐six PV patients who underwent 79 surgeries were matched with 312 controls. During hospitalization, 35 (44.3%) and 82 (25.9%) PV and control patients, respectively, were transfused with blood products. PV patients were at increased risk for transfusion intraoperatively (odds ratio [OR], 4.35; 95% confidence interval [CI], 1.79‐10.57; p = 0.001) and during hospitalization (OR, 4.35; 95% CI, 1.84‐10.31; p 
ISSN:0041-1132
1537-2995
DOI:10.1111/trf.13006