The biomechanical and histological effects of platelet-rich plasma on fracture healing

Purpose Platelet-rich plasma (PRP) includes growth factors and proteins that accelerate and stimulate bone regeneration and tissue recovery. The aim of this study was to evaluate the effects of PRP on fracture healing in terms of biomechanics and histology. Methods Seventy female rats were included...

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Published in:Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA sports traumatology, arthroscopy : official journal of the ESSKA, 2015-05, Vol.23 (5), p.1378-1383
Main Authors: Guzel, Yunus, Karalezli, Nazım, Bilge, Onur, Kacira, Burkay K., Esen, Hasan, Karadag, Hakan, Toker, Serdar, Göncü, Recep Gani, Doral, Mahmut Nedim
Format: Article
Language:English
Subjects:
Animals
Biomechanics
Disease Models, Animal
Experimental Study
Female
Femoral Fractures - pathology
Femoral Fractures - therapy
Fracture Healing - physiology
Fractures
Histology
Insulin-like growth factors
Mechanical engineering
Medicine
Medicine & Public Health
Orthopedics
Plasma
Platelet-Rich Plasma
Prospective Studies
Rats
Rats, Wistar
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Summary:Purpose Platelet-rich plasma (PRP) includes growth factors and proteins that accelerate and stimulate bone regeneration and tissue recovery. The aim of this study was to evaluate the effects of PRP on fracture healing in terms of biomechanics and histology. Methods Seventy female rats were included in this experimental study. They were divided into three groups: Group I (no PRP, n  = 30), Group II (PRP added, n  = 30) and Group III (control, n  = 10). The left femurs of the rats in Groups I and II were osteotomized and fixed by K-wires. Although no additional intervention was performed on Group I rats, PRP was applied to the fracture sites of Group II rats. The remaining ten rats were used as the control group of the biomechanical test (Group III). In the fourth week, nine femurs from Group I and ten femurs from Group II, and in the ninth week, nine femurs from each group were removed, and bone recovery was assessed histologically according to Modified Lane–Sandhu histological scoring criteria. Three-point bending test was applied to femurs for biomechanical evaluation in the ninth week. Results Histological healing was found to be significantly higher in Group II than in Group I ( p  
ISSN:0942-2056
1433-7347
DOI:10.1007/s00167-013-2734-2