Oxidant/antioxidant status in children and adolescents with immune thrombocytopenia (ITP) and the role of an adjuvant antioxidant therapy

Background Free oxygen radicals might have an adverse effect on platelets which might be reflected either on its count and/or degree of bleeding severity. Aim To assess oxidant‐antioxidant systems and evaluate effect of antioxidant therapy on platelet count (PC) and bleeding score (BS) in children a...

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Bibliographic Details
Published in:Pediatric blood & cancer 2015-05, Vol.62 (5), p.830-837
Main Authors: Elalfy, Mohssen S., Elhenawy, Yasmine I., Deifalla, Shaymaa, Hegazy, Marwa, Sabra, Amira, Abdelaziz, Yasmine
Format: Article
Language:English
Subjects:
Adolescent
Adolescents
Antioxidants
Antioxidants - metabolism
Antioxidants - therapeutic use
Bleeding
Blood Platelets
Cancer
Case-Control Studies
Catalase
Chemotherapy, Adjuvant
Child
Children
Chronic Disease
Female
Follow-Up Studies
Free radicals
Glutathione
Glutathione - metabolism
Hematology
Hemorrhage
Humans
Idiopathic thrombocytopenic purpura
Immune thrombocytopenia
Male
Malondialdehyde
MDA
Neoplasm Staging
Oncology
Oxidants - metabolism
Oxidative Stress
Pediatrics
Platelets
Prognosis
Prospective Studies
Purpura, Thrombocytopenic, Idiopathic - drug therapy
Purpura, Thrombocytopenic, Idiopathic - metabolism
Purpura, Thrombocytopenic, Idiopathic - pathology
Reactive oxygen species
Single-Blind Method
Systems analysis
TAC
Thrombocytopenia
Vitamin C
Vitamin E
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Summary:Background Free oxygen radicals might have an adverse effect on platelets which might be reflected either on its count and/or degree of bleeding severity. Aim To assess oxidant‐antioxidant systems and evaluate effect of antioxidant therapy on platelet count (PC) and bleeding score (BS) in children and adolescents with ITP. Methods Six months prospective randomized single blind study registered as (NCT 01763658) including 39 patients with newly diagnosed (ND) ITP; group 1 (G1) and 39 patients with chronic ITP (G2), each group was randomly allocated (2:1) to one of two subgroups respectively; (G1A and G2A) interventional arm received daily antioxidant therapy, while G1B and G2B; received a placebo. Both groups were compared with healthy controls (n = 39). The primary efficacy endpoints were the difference in the change from baseline to 6 month in ITP specific bleeding assessment tool (ITP‐BAT), PC, total antioxidant capacity (TAC), catalase (CAT), reduced glutathione (GSH) and serum malondialdehyde (MDA). Results Baseline TAC was significantly lower in patients with (ND) ITP compared to patients with chronic ITP (P 
ISSN:1545-5009
1545-5017
DOI:10.1002/pbc.25434