Whey peptide ingestion suppresses body fat accumulation in senescence-accelerated mouse prone 6 (SAMP6)

PURPOSE: Body weight in young growing and young adult animals was reduced by a high dietary density of whey protein concentrate; however, it is unclear whether dietary proteins similarly affect body weight in aging animals. Here, we examined whether whey protein or whey peptide ingestion suppressed...

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Bibliographic Details
Published in:European journal of nutrition 2015-06, Vol.54 (4), p.551-556
Main Authors: Ichinoseki-Sekine, Noriko, Kakigi, Ryo, Miura, Susumu, Naito, Hisashi
Format: Article
Language:English
Subjects:
acetyl-CoA carboxylase
Acetyl-CoA Carboxylase - genetics
Acetyl-CoA Carboxylase - metabolism
Adipose Tissue - drug effects
Adipose Tissue - metabolism
Aging
AMP-activated protein kinase
AMP-Activated Protein Kinases - genetics
AMP-Activated Protein Kinases - metabolism
Animals
beta oxidation
Body fat
body weight
casein
Chemistry
Chemistry and Materials Science
Diet
Eating
ingestion
Lipase - genetics
Lipase - metabolism
Lipid Metabolism - drug effects
Male
males
Mice
Muscle, Skeletal - drug effects
Muscle, Skeletal - metabolism
muscles
Nutrition
nutritional intervention
Original Contribution
Oxidation-Reduction
Peptides - administration & dosage
Phosphorylation
protein synthesis
skeletal muscle
triacylglycerol lipase
Western blotting
whey protein concentrate
Whey Proteins - administration & dosage
white adipose tissue
young adults
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Summary:PURPOSE: Body weight in young growing and young adult animals was reduced by a high dietary density of whey protein concentrate; however, it is unclear whether dietary proteins similarly affect body weight in aging animals. Here, we examined whether whey protein or whey peptide ingestion suppressed body fat accumulation and affected protein expression and phosphorylation in skeletal muscle in aging mice. METHODS: Twenty-six male senescence-accelerated mouse prone 6 (SAMP6) mice were assigned randomly to three dietary treatment groups: 18.7 % casein control (CON), 18.7 % whey protein (WPR), and 18.7 % whey peptide (WPE). After 28 weeks of treatment, skeletal tissues were dissected and weighed for analysis. Western blotting was performed to examine the expression of AMP-activated protein kinase (AMPK), acetyl-CoA carboxylase (ACC), and adipose triglyceride lipase (ATGL) in quadriceps muscles. RESULTS: Body (CON: 47.6 ± 2.2 g, WPR: 48.2 ± 2.7 g, WPE: 38.3 ± 2.0 g) and relative white adipose tissue (CON: 38.5 ± 3.5 mg/g, WPR: 43.8 ± 4.0 mg/g, WPE: 21.1 ± 4.4 mg/g) weights were lower in the WPE group compared with the other two groups (p 
ISSN:1436-6207
1436-6215
DOI:10.1007/s00394-014-0736-6