Relationship of maternal creatinine to first neonatal creatinine in infants <30 weeks gestation

Objective: To examine the relationship between maternal and neonatal creatinine (Cr) in preterm infants in the context of antenatal and intrapartum maternal and neonatal factors. Study Design: In this 5½-year, single-center, retrospective study, paired maternal and neonatal Cr were compared by t -te...

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Bibliographic Details
Published in:Journal of perinatology 2015-06, Vol.35 (6), p.401-404
Main Authors: Weintraub, A S, Carey, A, Connors, J, Blanco, V, Green, R S
Format: Article
Language:English
Subjects:
692/699/1585
Adult
Analysis
Birth Weight - physiology
Care and treatment
Chorionic Villi - pathology
Creatinine
Creatinine - blood
Design factors
Female
Gestation
Health aspects
Humans
Hypoxia
Infant, Newborn
Infant, Premature - physiology
Infants
Infants (Premature)
Ischemia
Lactates
Lactic acid
Male
Measurement
Medical examination
Medicine
Medicine & Public Health
Neonates
Newborn babies
original-article
Pediatric research
Pediatric Surgery
Pediatrics
Placenta
Pregnancy
Pregnancy, Multiple - physiology
Pregnant women
Regression analysis
Retrospective Studies
Ultrasound imaging
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Summary:Objective: To examine the relationship between maternal and neonatal creatinine (Cr) in preterm infants in the context of antenatal and intrapartum maternal and neonatal factors. Study Design: In this 5½-year, single-center, retrospective study, paired maternal and neonatal Cr were compared by t -test. Linear regression for correlated outcomes employing generalized estimating equations was used to examine neonatal Cr as a function of antenatal maternal Cr and potential confounders. Result: A total of 157 neonates of 124 mothers met study criteria. Neonatal Cr values in the first 24 h of life were significantly higher than antenatal maternal values. Linear regression modeling showed that maternal Cr, neonatal lactate, hypoxic–ischemic villous changes on placental pathology and multiple gestation were each significant determinants of the first neonatal Cr. Conclusion: No neonatal Cr was less than its paired maternal value. Maternal Cr, neonatal lactate, hypoxic–ischemic villous changes in the placenta and multiple gestation were each significantly associated with neonatal Cr.
ISSN:0743-8346
1476-5543
DOI:10.1038/jp.2014.232