Animal models of gastrointestinal and liver diseases. Animal models of visceral pain: pathophysiology, translational relevance, and challenges

Visceral pain describes pain emanating from the thoracic, pelvic, or abdominal organs. In contrast to somatic pain, visceral pain is generally vague, poorly localized, and characterized by hypersensitivity to a stimulus such as organ distension. Animal models have played a pivotal role in our unders...

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Bibliographic Details
Published in:American journal of physiology: Gastrointestinal and liver physiology 2015-06, Vol.308 (11), p.G885-G903
Main Authors: Greenwood-Van Meerveld, Beverley, Prusator, Dawn K, Johnson, Anthony C
Format: Article
Language:English
Subjects:
Animals
Gastrointestinal diseases
Gastrointestinal Diseases - metabolism
Gastrointestinal Diseases - physiopathology
Liver diseases
Liver Diseases - metabolism
Liver Diseases - physiopathology
Models, Animal
Nociception - drug effects
Nociception - physiology
Pain management
Pathology
Physiology
Therapies, Investigational - methods
Translational Medical Research
Visceral Pain - etiology
Visceral Pain - metabolism
Visceral Pain - physiopathology
Visceral Pain - psychology
Visceral Pain - therapy
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Summary:Visceral pain describes pain emanating from the thoracic, pelvic, or abdominal organs. In contrast to somatic pain, visceral pain is generally vague, poorly localized, and characterized by hypersensitivity to a stimulus such as organ distension. Animal models have played a pivotal role in our understanding of the mechanisms underlying the pathophysiology of visceral pain. This review focuses on animal models of visceral pain and their translational relevance. In addition, the challenges of using animal models to develop novel therapeutic approaches to treat visceral pain will be discussed.
ISSN:0193-1857
1522-1547
DOI:10.1152/ajpgi.00463.2014