Negative Effects of Acute Sleep Deprivation on Left Ventricular Functions and Cardiac Repolarization in Healthy Young Adults

• Published in: Pacing and clinical electrophysiology 2015-06, Vol.38 (6), p.713-722
• Main Authors: CAKICI, MUSA, DOGAN, ADNAN, CETIN, MUSTAFA, SUNER, ARIF, CANER, ASLI, POLAT, MUSTAFA, KAYA, HAKAN, ABUS, SABRI, AKTURK, ERDAL
• Format: Article
• Language: English
• Subjects: acute sleep deprivation; Adult; Cross-Over Studies; Diastole; Echocardiography; Electrocardiography; Female; Healthy Volunteers; Heart Conduction System - diagnostic imaging; Heart Conduction System - physiopathology; Humans; left ventricular diastolic function; Male; QT interval; Sleep Deprivation - diagnostic imaging; Sleep Deprivation - physiopathology; Tp-e interval; Ventricular Dysfunction, Left - diagnostic imaging; Ventricular Dysfunction, Left - physiopathology
• ISSN: 0147-8389; 1540-8159
• DOI: 10.1111/pace.12534

Background Sleep deprivation (SD) is associated with an increased incidence of adverse cardiovascular events, we aimed to determine the impact of acute SD on structural and functional alterations of the left ventricle (LV) and on electrocardiogram (ECG) markers including T wave peak‐to‐end interval (TpTe), QT interval, and TpTe/QT ratio in healthy subjects after a night of SD. Methods The study population consisted of 40 healthy young adults (19 males, 21 females; mean age: 28.2 ± 3.86 years). Echocardiographic images and ECGs were obtained from the participants after a night of regular sleep (RS) and SD. The average sleep time of the subjects was 6.67 ± 1.76 hours during RS and 1.25 ± 0.74 hours during a night of SD. Results The myocardial performance index, isovolumic relaxation time, and deceleration time values were significantly higher after SD. In addition, the corrected TpTe interval, corrected QT interval (QTc) max, and TpTe/QT ratio were significantly increased after a night of SD when compared with a night of RS (78.5 ± 6.8 ms vs 70.7 ± 7.6 ms, P < 0.001; 407.5 ± 18.6 ms vs 395.07 ± 21.3 ms, P = 0.001; and 0.189 ± 0.014 ms vs 0. 0.179 ± 0.016 ms, P < 0.001, respectively). However, subjects had similar QTp interval values (defined as beginning of the QRS complex to peak of the T wave) after a night of SD as a night of RS (294.6 ± 19.0 vs 291.9 ± 18.5, P = 233). Conclusion Our crossover study revealed the presence of subclinical LV diastolic functional changes and increased QT intervals, TpTe intervals, and TpTe/QT ratios in healthy young adults after one night SD. Therefore, the increased QT interval occurred secondary to the increased TpTe interval in this population.