Comparison of methods of estimating the mother-to-child transmission rate of human immunodeficiency virus type 1 (HIV-1)

Four methods of estimating mother-to-child transmission rates of human immunodeficiency virus type 1 (HIV-1), based on the 1992 Ghent workshop, were compared in a multicenter New York City prospective cohort study in 1986-1992. Of 833 infants born to women at risk of HIV-1 infection, 388 were born H...

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Bibliographic Details
Published in:American journal of epidemiology 1995-10, Vol.142 (7), p.714-718
Main Authors: MATHESON, P. B, WEEDON, J, HUTSON, D, THOMAS, P. A, CAPPELLI, M, ABRAMS, E. J, SHAFFER, N, MAHRUKH BAMJI, KRASINSKI, K, LAMBERT, G, ADITYA KAUL, GRIMM, K
Format: Article
Language:English
Subjects:
Biological and medical sciences
human immunodeficiency virus 1
Immunodeficiencies
Immunodeficiencies. Immunoglobulinopathies
Immunopathology
Medical sciences
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Summary:Four methods of estimating mother-to-child transmission rates of human immunodeficiency virus type 1 (HIV-1), based on the 1992 Ghent workshop, were compared in a multicenter New York City prospective cohort study in 1986-1992. Of 833 infants born to women at risk of HIV-1 infection, 388 were born HIV-1 seropositive and 445 were HIV-1 seronegative. The four methods, the Antibody Only, Indirect, Direct, and Virologic Methods, yielded transmission rate estimates of 19-25%, classifying 59-89% of the cohort. Estimation based on persistence of HIV-1 antibody and clinical assessment yielded transmission rates similar to those methods that incorporated virologic testing.
ISSN:0002-9262
1476-6256
DOI:10.1093/oxfordjournals.aje.a117701