Topical use of autologous platelet rich plasma in myringoplasty

Abstract Objective The aim of this study was to assess the topical use of autologous platelet rich plasma (PRP) to improve success rate of myringoplasty. Methods This study was carried out on 64 patients with large dry central tympanic membrane perforations. Myringoplasty was performed through posta...

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Bibliographic Details
Published in:Auris, nasus, larynx nasus, larynx, 2015-10, Vol.42 (5), p.365-368
Main Authors: El-Anwar, Mohammad Waheed, El-Ahl, Magdy Abdalla Sayed, Zidan, Amal Ahmad, Yacoup, Mohammad Abdel-Rhman Abdel-Salam
Format: Article
Language:English
Subjects:
Administration, Topical
Adolescent
Adult
Child
Ear Cartilage - transplantation
Female
Hearing Tests
Humans
Male
Middle Aged
Myringoplasty
Myringoplasty - methods
Otitis Media, Suppurative - complications
Otitis Media, Suppurative - therapy
Otolaryngology
Platelet rich plasma
Treatment Outcome
Tympanic membrane
Tympanic Membrane Perforation - etiology
Tympanic Membrane Perforation - therapy
Wound Healing
Young Adult
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Summary:Abstract Objective The aim of this study was to assess the topical use of autologous platelet rich plasma (PRP) to improve success rate of myringoplasty. Methods This study was carried out on 64 patients with large dry central tympanic membrane perforations. Myringoplasty was performed through postauricular approach by underlay graft using conchal perichondrial graft. Patients were classified into two groups: case group included 32 patients who had undergone myringoplasty with use of autologous PRP and control group included 32 patients who had undergone myringoplasty without use of autologous PRP. Results Both groups were statistically matched with regard to age and sex. At 6 months postoperatively, success rate (graft taking) in case group (100%) was significantly higher than in control group (81.25%) ( P = 0.02). Success in terms of hearing gain (≥10 dB) was achieved in 21 patients (65.6%) in case group and 11 patients (34.4%) in control group with statistically non-significant difference ( P = 0.079). Infection rate in control group (12.5%) was found to be significantly higher than in case group ( P < 0.0001). Conclusion Topical autologous PRP application during myringolpasty is safe and highly efficient and successful with no reported complication. PRP not only enhances healing of chronic TM perforations but also avoids infection and obviates the need for inner EAC pack.
ISSN:0385-8146
1879-1476
DOI:10.1016/j.anl.2015.02.016