IgA, IgA Subclasses, and Secretory Component Levels in Oral Fluid Collected from Subjects after Parenteral Influenza Vaccination

We investigated the relationship between the response observed in oral fluid and mucosal immunity in the upper respiratory tract and also the IgA subclass distribution in oral fluid to determine if antibodies were in fact actively secreted. Oral fluid samples were collected with a sampling device ma...

Full description

Saved in:
Bibliographic Details
Published in:The Journal of infectious diseases 1995-04, Vol.171 (4), p.1072-1073
Main Authors: Brokstad, Karl A., Cox, Rebecca J., Oxford, John S., Haaheim, Lars R.
Format: Article
Language:English
Subjects:
Antibodies
Blood
Enzyme linked immunosorbent assay
Influenza vaccines
influenza virus
Lymphocytes
Monoclonal antibodies
Orthomyxoviridae
Palatine tonsils
Secretion
Vaccination
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We investigated the relationship between the response observed in oral fluid and mucosal immunity in the upper respiratory tract and also the IgA subclass distribution in oral fluid to determine if antibodies were in fact actively secreted. Oral fluid samples were collected with a sampling device made of an absorbent pad on a stick. A good correlation was noted in all subjects between the specific levels of IgA and SC (r = .99, P < .001) and between IgA1 plus IgA2 and SC (r = .91-.99, P < .001) against the 3 vaccine strains. Not surprisingly, we found IgA1 to be the most abundant subclass of the total (66%) and influenza virus-specific (54%-58%) IgA in the oral fluid. IgA1 is the most common subclass of IgA in serum ( similar to 85% IgA1) and in most mucosal secretions (50%-67% IgA1), except in secretions from the large intestine and the female genital tract, in which IgA2 is equally or more abundant.
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/171.4.1072-a