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Cancer-like metabolism of the mammalian retina

The retina, like many cancers, produces energy from glycolysis even in the presence of oxygen. This phenomenon is known as aerobic glycolysis and eponymously as the Warburg effect. In recent years, the Warburg effect has become an explosive area of study within the cancer research community. The exp...

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Published in:	Clinical & experimental ophthalmology 2015-05, Vol.43 (4), p.367-376
Main Authors:	Ng, Soo Khai, Wood, John PM, Chidlow, Glyn, Han, Guoge, Kittipassorn, Thaksaon, Peet, Daniel J, Casson, Robert J
Format:	Article
Language:	English
Subjects:	aerobic glycolysis Animals Cancer Energy Metabolism - physiology Glycolysis - physiology HIF-1 Humans mammalian retina Metabolism Neoplasms - metabolism Oxidative Phosphorylation Oxygen - physiology PKM2 Pyruvate Kinase - metabolism Retina Retina - metabolism Warburg effect
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creator	Ng, Soo Khai Wood, John PM Chidlow, Glyn Han, Guoge Kittipassorn, Thaksaon Peet, Daniel J Casson, Robert J
description	The retina, like many cancers, produces energy from glycolysis even in the presence of oxygen. This phenomenon is known as aerobic glycolysis and eponymously as the Warburg effect. In recent years, the Warburg effect has become an explosive area of study within the cancer research community. The expanding knowledge about the molecular mechanisms underpinning the Warburg effect in cancer promises to provide a greater understanding of mammalian retinal metabolism and has motivated cancer researchers to target the Warburg effect as a novel treatment strategy for cancer. However, if the molecular mechanisms underlying the Warburg effect are shared by the retina and cancer, treatments targeting the Warburg effect may have serious adverse effects on retinal metabolism. Herein, we provide an updated understanding of the Warburg effect in mammalian retina.
doi_str_mv	10.1111/ceo.12462
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subjects	aerobic glycolysis Animals Cancer Energy Metabolism - physiology Glycolysis - physiology HIF-1 Humans mammalian retina Metabolism Neoplasms - metabolism Oxidative Phosphorylation Oxygen - physiology PKM2 Pyruvate Kinase - metabolism Retina Retina - metabolism Warburg effect
title	Cancer-like metabolism of the mammalian retina
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