Encapsulating Ionic Liquid and Fe3O4 Nanoparticles in Gelatin Microcapsules as Microwave Susceptible Agent for MR Imaging-guided Tumor Thermotherapy

The combination of therapies and monitoring the treatment process has become a new concept in cancer therapy. Herein, gelatin-based microcapsules have been first reported to be used as microwave (MW) susceptible agent and magnetic resonance (MR) imaging contrast agent for cancer MW thermotherapy. Us...

Full description

Saved in:
Bibliographic Details
Published in:ACS applied materials & interfaces 2015-06, Vol.7 (24), p.13612-13619
Main Authors: Du, Qijun, Ma, Tengchuang, Fu, Changhui, Liu, Tianlong, Huang, Zhongbing, Ren, Jun, Shao, Haibo, Xu, Ke, Tang, Fangqiong, Meng, Xianwei
Format: Article
Language:English
Subjects:
Animals
Capsules
Contrast Media - chemistry
Gelatin - chemistry
Hyperthermia, Induced - methods
Ionic Liquids - chemistry
Magnetic Resonance Imaging - methods
Magnetite Nanoparticles - chemistry
Mice
Mice, Inbred ICR
Microwaves
Neoplasms - metabolism
Neoplasms - therapy
Rabbits
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The combination of therapies and monitoring the treatment process has become a new concept in cancer therapy. Herein, gelatin-based microcapsules have been first reported to be used as microwave (MW) susceptible agent and magnetic resonance (MR) imaging contrast agent for cancer MW thermotherapy. Using the simple coacervation methods, ionic liquid (IL) and Fe3O4 nanoparticles (NPs) were wrapped in microcapsules, and these microcapsules showed good heating efficacy in vitro under MW irradiation. The results of cell tests indicated that gelatin/IL@Fe3O4 microcapsules possessed excellent compatibility in physiological environments, and they could effectively kill cancer cells with exposure to MW. The ICR mice bearing H22 tumors treated with gelatin/IL@Fe3O4 microcapsules were obtained an outstanding MW thermotherapy efficacy with 100% tumor elimination under ultralow density irradiation (1.8 W/cm2, 450 MHz). In addition, the applicability of the microcapsules as an efficient contrast agent for MR imaging in vivo was evident. Therefore, these multifunctional microcapsules have a great potential for MR imaging-guided MW thermotherapy.
ISSN:1944-8244
1944-8252
DOI:10.1021/acsami.5b03230