Calcification of subcutaneously implanted collagens in relation to cytotoxicity, cellular interactions and crosslinking

Calcification of biomaterials occurs generally through an interaction of host and implanted material factors, but up to now the real origin of pathologic calcification is unknown. In this study, the incidence of calcification of (crosslinked) dermal sheep collagens (DSCs) was investigated with respe...

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Bibliographic Details
Published in:Journal of materials science. Materials in medicine 1995-05, Vol.6 (5), p.288-296
Main Authors: Van Luyn, M. J. A., Van Wachem, P. B., Dijkstra, P. J., Olde Damink, L. H. H., Feijen, J.
Format: Article
Language:English
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Summary:Calcification of biomaterials occurs generally through an interaction of host and implanted material factors, but up to now the real origin of pathologic calcification is unknown. In this study, the incidence of calcification of (crosslinked) dermal sheep collagens (DSCs) was investigated with respect to their specific properties, during subcutaneous implantation in rats. Three types of DSCs were commercially obtained: non-crosslinked DSC, DSC crosslinked with gluteraldehyde and hexamethylenediisocyanate. From the results, no relation was found between cellular infiltration of DSCs and calcification. However, from the use of different types and modification of crosslinking methods it might be concluded that calcification is mainly related to stable crosslinks, i.e. to the chemical properties of the obtained material.
ISSN:0957-4530
1573-4838
DOI:10.1007/BF00120273