Expression profiling associates blood and brain glucocorticoid receptor signaling with trauma-related individual differences in both sexes

Significance Because posttraumatic stress disorder (PTSD) occurs in a subset of trauma-exposed persons, expression profiling in the context of an animal model that focuses on individual differences in stress response permits identification of the relevant signaling pathways that lead to sustained im...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 2014-09, Vol.111 (37), p.13529-13534
Main Authors: Daskalakis, Nikolaos P., Cohen, Hagit, Cai, Guiqing, Buxbaum, Joseph D., Yehuda, Rachel
Format: Article
Language:English
Subjects:
Amygdala
Amygdala - metabolism
Animal models
Animals
Behavior, Animal
Biological markers
Biological Sciences
Biomarkers
Blood
Brain
Brain - metabolism
Brain - pathology
Corticosterone - pharmacology
Corticosterone - therapeutic use
Datasets
Female
Gene expression
Gene Expression Profiling
Gene Regulatory Networks
Genes
Hippocampus
Hippocampus - metabolism
Male
Military psychiatry
Post traumatic stress disorder
Predatory Behavior - drug effects
Rats, Sprague-Dawley
Receptors, Glucocorticoid - blood
Receptors, Glucocorticoid - genetics
Rodents
Sex Characteristics
Signal Transduction
Stress Disorders, Post-Traumatic - blood
Stress Disorders, Post-Traumatic - drug therapy
Stress Disorders, Post-Traumatic - genetics
Tissues
Transcription factors
Trauma
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Description
Summary:Significance Because posttraumatic stress disorder (PTSD) occurs in a subset of trauma-exposed persons, expression profiling in the context of an animal model that focuses on individual differences in stress response permits identification of the relevant signaling pathways that lead to sustained impairment or resilience. The inclusion of blood and brain samples from both sexes is important because it allows the detection of convergent susceptibility pathways and concomitant identification of blood-based biomarkers. The across tissue and sex involvement of glucocorticoid receptor signaling with exposure-related individual differences suggests that targeting this signaling pathway may lead to a promising therapeutic strategy in PTSD.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.1401660111