Antimicrobial Efficacy of a Historical High-Frequency Plasma Apparatus in Comparison With 2 Modern, Cold Atmospheric Pressure Plasma Devices

Background. Today, highly sophisticated devices deliver cold atmospheric pressure plasma (CAPP) with a multitude of bioactive properties, opening the window to a new medical field: plasma medicine. Different techniques to create the optimal plasma device for different medical indications are current...

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Bibliographic Details
Published in:Surgical innovation 2015-08, Vol.22 (4), p.394-400
Main Authors: Daeschlein, Georg, Napp, Matthias, von Podewils, Sebastian, Scholz, Sebastian, Arnold, Andreas, Emmert, Steffen, Haase, Hermann, Napp, Judith, Spitzmueller, Romy, Gümbel, Denis, Jünger, Michael
Format: Article
Language:English
Subjects:
Anti-Infective Agents - chemistry
Anti-Infective Agents - pharmacology
Bacteria - drug effects
Biofilms - drug effects
Biomedical Engineering - instrumentation
Biomedical Engineering - methods
Electrodes
Equipment Design
Models, Biological
Plasma Gases - chemistry
Plasma Gases - pharmacology
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Summary:Background. Today, highly sophisticated devices deliver cold atmospheric pressure plasma (CAPP) with a multitude of bioactive properties, opening the window to a new medical field: plasma medicine. Different techniques to create the optimal plasma device for different medical indications are currently being explored. However, even a 100 years ago, CAPP was briefly used in the related form of high-frequency therapy. The objective of our study was to compare historic with modern techniques regarding antimicrobial efficacy. Methods. First, 26 different clinical isolates of relevant wound pathogens were treated in vitro with a historic violet wand (VW) and 2 modern plasma sources (kINPen 09 and dielectric barrier discharge [DBD]) and the obtained inhibition areas (IAs) were compared. Second, a biofilm model was used to compare biofilm inactivation by VW, DBD, ethanol, and polyhexanide treatment. Results. DBD with the largest electrode produced the largest IAs. VW showed results similar to 2 different modes of the kINPen 09. IAs of VW were enlargeable by attaching a larger electrode. Against biofilms, VW was less effective than DBD but more effective than ethanol 70% and polyhexanide. Conclusion. The proven antimicrobial efficacy of VW may encourage the development of new, potent plasma devices based on the very simple and inexpensive technique of the historic high-frequency apparatus.
ISSN:1553-3506
1553-3514
DOI:10.1177/1553350615573584