Salivary biomarkers of oxidative stress: A critical review

Human saliva is an increasingly attractive medium for biomarker discovery due to its amenability to noninvasive and repeated sampling, ease of collection and processing, and suitability for single analyte or metabolomic measurements. Salivary biomarkers of oxidative stress reflect local and systemic...

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Bibliographic Details
Published in:Free radical biology & medicine 2015-08, Vol.85, p.95-104
Main Authors: Wang, Jessica, Schipper, Hyman M., Velly, Ana M., Mohit, Shrisha, Gornitsky, Mervyn
Format: Article
Language:English
Subjects:
Biomarker
Biomarkers - metabolism
Diagnosis
Disease - classification
Guidelines
Humans
Oxidative Stress
Saliva
Saliva - metabolism
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Summary:Human saliva is an increasingly attractive medium for biomarker discovery due to its amenability to noninvasive and repeated sampling, ease of collection and processing, and suitability for single analyte or metabolomic measurements. Salivary biomarkers of oxidative stress reflect local and systemic pathologies and may inform on the diagnosis, prognosis, and therapeutic responsiveness of numerous human diseases. However, for many of the disorders investigated, data reporting on alterations in salivary redox homeostasis are often highly conflicted across studies. We surveyed the available biomedical literature on this topic and noted significant discrepancies in the study designs, target populations, and operating procedures which likely contribute to the discordant data sets reported. Based on these observations, guidelines are provided to minimize interlaboratory variability in redox biomarker discovery based on human saliva. •Human saliva is a noninvasive and easily collected medium for biomarker discovery.•Salivary biomarkers of oxidative stress reflect local and systemic pathologies.•Available literature on salivary biomarkers shows significant discrepancies.•Guidelines are provided to minimize variability in salivary biomarker discovery.
ISSN:0891-5849
1873-4596
DOI:10.1016/j.freeradbiomed.2015.04.005