Rattlesnake Toxins Alter Development of Muscle Cells in Culture

The neurotoxic phospholipase A sub(2) complexes that are present in rattlesnake venoms block neuromuscular transmission and also induce damage to muscle tissue. Mojave toxin from Crotalus scutulatus scutulatus and crotoxin from Crotalus durissus terrificus, phospholipase-based neurotoxins with demon...

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Bibliographic Details
Published in:Annals of the New York Academy of Sciences 1994-01, Vol.710 (1), p.126-141
Main Authors: BIEBER, ALLAN L., ZIOLKOWSKI, C., D'AVIS, PATRICIA A.
Format: Article
Language:English
Subjects:
Acetylcholinesterase - metabolism
Animals
Animals, Newborn
Cell Fusion - drug effects
Cells, Cultured
Creatine Kinase - metabolism
Crotalid Venoms - toxicity
Crotalus durissus terrificus
Crotalus scutulatus scutulatus
DNA - metabolism
Muscles - cytology
Muscles - drug effects
Muscles - metabolism
Neurotoxins - toxicity
Proteins - metabolism
Rats
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Summary:The neurotoxic phospholipase A sub(2) complexes that are present in rattlesnake venoms block neuromuscular transmission and also induce damage to muscle tissue. Mojave toxin from Crotalus scutulatus scutulatus and crotoxin from Crotalus durissus terrificus, phospholipase-based neurotoxins with demonstrated myotoxic activity, are the most intensively studied proteins in this class. Mojave toxin is a highly toxic heterodimeric phospholipase complex that can be dissociated into two distinct subunits. The phospholipase A sub(2) activity resides with a basic subunit that is less toxic than the native toxin. The acidic subunit is devoid of enzymatic activity and is not toxic.
ISSN:0077-8923
1749-6632
DOI:10.1111/j.1749-6632.1994.tb26620.x