The NMDA antagonist procyclidine, but not ifenprodil, enhances the protective efficacy of common antiepileptics against maximal electroshock-induced seizures in mice

Procyclidine did not influence the electroconvulsive threshold per se, but when given in a dose of 10 mg/kg, it potentiated the protective activity of carbamazepine, diphenylhydantoin, phenobarbital and valproate, and in a dose of 20 mg/kg, that of diazepam against maximal electroshock-induced convu...

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Bibliographic Details
Published in:Journal of Neural Transmission 1994-01, Vol.97 (1), p.1-12
Main Authors: ZARNOWSKI, T, KLEINROK, Z, TURSKI, W. A, CZUCZWAR, S. J
Format: Article
Language:English
Subjects:
Anticonvulsants. Antiepileptics. Antiparkinson agents
Biological and medical sciences
Medical sciences
Neuropharmacology
Pharmacology. Drug treatments
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Summary:Procyclidine did not influence the electroconvulsive threshold per se, but when given in a dose of 10 mg/kg, it potentiated the protective activity of carbamazepine, diphenylhydantoin, phenobarbital and valproate, and in a dose of 20 mg/kg, that of diazepam against maximal electroshock-induced convulsions in mice. Ifenprodil increased the threshold for electroconvulsions when applied at 20 and 40 mg/kg (i.p.), but surprisingly, when combined with all antiepileptics tested, it did not influence their anticonvulsant actions. The combined treatment of procyclidine with carbamazepine, diphenylhydantoin, phenobarbital or valproate, as well as procyclidine with diazepam caused significant worsening of long-term memory. It may be concluded that not all agents interfering with NMDA receptor complex-mediated events lead to the potentiation of the anticonvulsant activity of antiepileptic drugs.
ISSN:0300-9564
1435-1463
DOI:10.1007/bf01277958