Complex Reconfiguration of DNA Nanostructures

Nucleic acids have been used to create diverse synthetic structural and dynamic systems. Toehold‐mediated strand displacement has enabled the construction of sophisticated circuits, motors, and molecular computers. Yet it remains challenging to demonstrate complex structural reconfiguration in which...

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Bibliographic Details
Published in:Angewandte Chemie 2014-07, Vol.126 (29), p.7605-7609
Main Authors: Wei, Bryan, Ong, Luvena L., Chen, Jeffrey, Jaffe, Alexander S., Yin, Peng
Format: Article
Language:English
Subjects:
Brick
Chemistry
Deoxyribonucleic acid
DNA
DNA-Architekturen
Dynamical systems
Dynamics
Einzelstrangkacheln
Molecular structure
Motors
Nanostrukturen
Reconfiguration
Strands
Strangaustausch
Strukturrekonfiguration
Three dimensional
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Summary:Nucleic acids have been used to create diverse synthetic structural and dynamic systems. Toehold‐mediated strand displacement has enabled the construction of sophisticated circuits, motors, and molecular computers. Yet it remains challenging to demonstrate complex structural reconfiguration in which a structure changes from a starting shape to another arbitrarily prescribed shape. To address this challenge, we have developed a general structural‐reconfiguration method that utilizes the modularly interconnected architecture of single‐stranded DNA tile and brick structures. The removal of one component strand reveals a newly exposed toehold on a neighboring strand, thus enabling us to remove regions of connected component strands without the need to modify the strands with predesigned external toeholds. By using this method, we reconfigured a two‐dimensional rectangular DNA canvas into diverse prescribed shapes. We also used this method to reconfigure a three‐dimensional DNA cuboid. Schnitzen von DNA‐Nanostrukturen: Die modular verzahnte Architektur einzelsträngiger Kachel‐ und Ziegelstein‐Strukturen wurde genutzt, um eine allgemeine Methode für die Strukturrekonfiguration zu entwickeln. Das Entfernen eines Stranges (siehe Bild) legt einen neuen Haltepunkt an einem Nachbarstrang frei, sodass es gelingt, Abschnitte aus verbundenen Strängen auszuschneiden, ohne dass die Stränge mit vorab entworfenen externen Haltepunkten modifiziert werden müssten.
ISSN:0044-8249
1521-3757
DOI:10.1002/ange.201402437