Time-dependent biodistribution, clearance and biocompatibility of magnetic fibrin nanoparticles: an in vivo study

Recently, bioretention and toxicity of injected nanoparticles in the body has drawn much attention in biomedical research. In the present study, 5 mg Fe per kg body weight of magnetic fibrin nanoparticles (MFNPs) were injected into mice intravenously and investigated for their blood clearance profil...

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Bibliographic Details
Published in:Nanoscale 2015-06, Vol.7 (21), p.9676-9685
Main Authors: Prabu, Periyathambi, Vedakumari, Weslen S, Sastry, Thotapalli P
Format: Article
Language:English
Subjects:
Animals
Biocompatibility
Biocompatible Materials - chemistry
Biocompatible Materials - pharmacokinetics
Blood
Body Weight
Clearances
Dynamic Light Scattering
Female
Fibrin
Fibrin - chemistry
Hemolysis
Iron
Liver - metabolism
Liver - pathology
Magnetite Nanoparticles - chemistry
Mice
Mice, Inbred BALB C
Nanoparticles
Spleen
Spleen - metabolism
Spleen - pathology
Time Factors
Tissue Distribution
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Summary:Recently, bioretention and toxicity of injected nanoparticles in the body has drawn much attention in biomedical research. In the present study, 5 mg Fe per kg body weight of magnetic fibrin nanoparticles (MFNPs) were injected into mice intravenously and investigated for their blood clearance profile, biodistribution, haematology and pathology studies for a time period of 28 days. Moderately long circulation of MFNPs in blood was observed with probable degradation and excretion into the bloodstream via monoatomic iron forms. Inductively coupled plasma optical emission spectrometry (ICP-OES) and Prussian blue staining results showed increased accumulation of MFNPs in the liver, followed by spleen and other organs. Body weight, spleen/thymus indexes, haematology, serum biochemistry and histopathology studies demonstrated that MFNPs were biocompatible. These results suggest the feasibility of using MFNPs for drug delivery and imaging applications. Recently, bioretention and toxicity of injected nanoparticles in the body has drawn much attention in biomedical research.
ISSN:2040-3364
2040-3372
2040-3372
DOI:10.1039/c5nr00113g