Impact of intravenous lipid emulsions on liver function tests: Contribution of parenteral fish oil

Abstract Objective Lipids in parenteral nutrition (PN) have been linked to liver damage. The aim of this study is to 1) determine whether the incidence of alterations in liver function tests (LFTs) changes over time among hospitalized adult patients receiving PN; 2) evaluate whether the alteration i...

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Bibliographic Details
Published in:Nutrition (Burbank, Los Angeles County, Calif.) Los Angeles County, Calif.), 2015-09, Vol.31 (9), p.1109-1116
Main Authors: Badia-Tahull, Maria B., Pharm.D, Llop-Talaveron, Josep, Pharm.D, Leiva-Badosa, Elisabet, Pharm.D
Format: Article
Language:English
Subjects:
Aged
Alanine Transaminase - blood
Alkaline Phosphatase - blood
Bilirubin - blood
Cancer
Cholestasis
Confidence intervals
Dietary Fats, Unsaturated - adverse effects
Dietary Fats, Unsaturated - pharmacology
Emulsions
Fat emulsions
Fat Emulsions, Intravenous - adverse effects
Fat Emulsions, Intravenous - chemistry
Fat Emulsions, Intravenous - pharmacology
Female
Fish oils
Fish Oils - pharmacology
gamma-Glutamyltransferase - blood
Gastroenterology and Hepatology
Glucose
Hospitalization
Hospitals
Humans
Intravenous
Lipids
Liver - drug effects
Liver - metabolism
Liver Function Tests
Male
Metabolism
Middle Aged
Mortality
Multivariate analysis
Nutrition
Parenteral nutrition
Parenteral Nutrition - adverse effects
Parenteral Nutrition Solutions - adverse effects
Parenteral Nutrition Solutions - chemistry
Parenteral Nutrition Solutions - pharmacology
Pediatrics
Phosphatase
Plant Oils - adverse effects
Statistical models
Studies
Triglycerides
Values
Variables
ω-3 fatty acids
ω-6 fatty acids
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Summary:Abstract Objective Lipids in parenteral nutrition (PN) have been linked to liver damage. The aim of this study is to 1) determine whether the incidence of alterations in liver function tests (LFTs) changes over time among hospitalized adult patients receiving PN; 2) evaluate whether the alteration in LFTs varies with the pattern of lipid administration; and 3) study the relationship between LFT alterations and fish oil (FO) emulsions. Methods Patients treated with PN over 4 y were included. Demographic, clinical, nutritional, and analytical variables were collected. LFTs (γ-glutamyl transferase [GGT], alkaline phosphatase [AP], alanine aminotransferase [ALT], and total bilirubin [BIL]) were collected during PN treatment. Differences in LFTs were studied with t tests for paired samples. To match the type of lipid with each of the LFTs studied, four multivariate statistical models were performed. Significance was reported with the 95% confidence interval (CI) at p  
ISSN:0899-9007
1873-1244
DOI:10.1016/j.nut.2015.04.005