Effects of supplementation with green tea catechins on plasma C-reactive protein concentrations: A systematic review and meta-analysis of randomized controlled trials

Abstract Background Promising experimental and clinical trials suggest that green tea decreases the inflammatory process in cardiometabolic diseases, but evidence from epidemiologic studies about the effects on plasma C-reactive protein (CRP) seems inconsistent and ambiguous. Therefore, the aim of t...

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Published in:Nutrition (Burbank, Los Angeles County, Calif.) Los Angeles County, Calif.), 2015-09, Vol.31 (9), p.1061-1071
Main Authors: Serban, Corina, M.D., Ph.D, Sahebkar, Amirhossein, Ph.D., Pharm.D, Antal, Diana, M.D., Ph.D, Ursoniu, Sorin, M.D., Ph.D, Banach, Maciej, M.D., Ph.D., F.A.H.A., F.N.L.A., F.E.S.C., F.A.S.A
Format: Article
Language:English
Subjects:
Alzheimer's disease
Anti-Inflammatory Agents - pharmacology
Bias
Blood pressure
Body mass index
C-reactive protein
C-Reactive Protein - metabolism
Camellia sinensis - chemistry
Cardiovascular disease
Catechin - pharmacology
Catechins
Chemical elements
Cholesterol
Diabetes
Dietary Supplements
DNA methylation
Gastroenterology and Hepatology
Green tea
Homeostasis
Humans
Hypertension
Inflammation
Inflammation - blood
Insulin resistance
Lipoproteins
Plant Extracts - pharmacology
Plasma
Polyphenols
Proteins
Quality
Sensitivity analysis
Signal transduction
Studies
Tea
Tea - chemistry
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Summary:Abstract Background Promising experimental and clinical trials suggest that green tea decreases the inflammatory process in cardiometabolic diseases, but evidence from epidemiologic studies about the effects on plasma C-reactive protein (CRP) seems inconsistent and ambiguous. Therefore, the aim of this meta-analysis was to evaluate the effects of green tea supplementation on plasma CRP concentrations. Methods We searched selected database up to October 26, 2014 to identify randomized controlled trials (RCTs) investigating the effects of green tea supplementation on plasma CRP concentrations. Two independent reviewers extracted data on study characteristics, methods, and outcomes. Results Meta-analysis of data from 11 RCTs arms did not indicate a significant effect of supplementation with green tea catechins on plasma CRP concentrations (weighted mean difference [WMD], 0.085 mg/L; 95% confidence interval [CI], −0.225 to 0.395; P  = 0.592). This effect size was robust in sensitivity analysis and omission of each individual study did not have a significant effect. The nonsignificant effects of green tea catechins on plasma CRP concentrations were also observed in subgroups of studies with green tea supplementation with a duration of
ISSN:0899-9007
1873-1244
DOI:10.1016/j.nut.2015.02.004