“Paper Machine” for Molecular Diagnostics

Clinical tests based on primer-initiated amplification of specific nucleic acid sequences achieve high levels of sensitivity and specificity. Despite these desirable characteristics, these tests have not reached their full potential because their complexity and expense limit their usefulness to cent...

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Bibliographic Details
Published in:Analytical chemistry (Washington) 2015-08, Vol.87 (15), p.7595-7601
Main Authors: Connelly, John T, Rolland, Jason P, Whitesides, George M
Format: Article
Language:English
Subjects:
Amplification
Analytical chemistry
blood
buffers
cameras
Cells
Deoxyribonucleic acid
detection limit
Devices
diagnostic techniques
DNA
E coli
Escherichia coli
Evaporation
genes
Humans
Lamps
loop-mediated isothermal amplification
Microfluidic Analytical Techniques - economics
Microfluidic Analytical Techniques - instrumentation
Molecular Diagnostic Techniques - instrumentation
Molecular Diagnostic Techniques - methods
Molecules
Nucleic acids
nucleotide sequences
Paper machines
Point-of-Care Systems
Reagents
Reproduction
Sample preparation
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