Embolization of left spermatic vein in non-obstructive azoospermic men with varicocele: role of FSH to predict the appearance of ejaculated spermatozoa after treatment

Purpose Varicocele repair in non-obstructive azoospermia (NOA) was occasionally associated to ejaculated spermatozoa independently from clinical and laboratory measures. We performed a prospective study in infertile men affected by NOA and left side varicocele to find whether or not the appearance o...

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Bibliographic Details
Published in:Journal of endocrinological investigation 2015-07, Vol.38 (7), p.785-790
Main Authors: D’Andrea, S., Giordano, A. V., Carducci, S., Sacchetti, L., Necozione, S., Costanzo, M., De Gregorio, A., Micillo, A., Francavilla, F., Francavilla, S., Barbonetti, A.
Format: Article
Language:English
Subjects:
Adult
Azoospermia - blood
Azoospermia - surgery
Ejaculation
Embolization, Therapeutic
Endocrinology
Follicle Stimulating Hormone - blood
Humans
Male
Medicine
Medicine & Public Health
Metabolic Diseases
Middle Aged
Original Article
Spermatozoa
Treatment Outcome
Varicocele - surgery
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Summary:Purpose Varicocele repair in non-obstructive azoospermia (NOA) was occasionally associated to ejaculated spermatozoa independently from clinical and laboratory measures. We performed a prospective study in infertile men affected by NOA and left side varicocele to find whether or not the appearance of ejaculated spermatozoa after varicocele repair is predicted by baseline measures. Methods Patients with NOA and grade II, or grade III left side varicocele were submitted to hormone analysis and to scrotal color Doppler ultrasound (CDU). Azoospermia was confirmed in 23 patients aged 25–47 years who were than submitted to varicocele repair through a retrograde internal spermatic vein embolization. Patients were re-evaluated after 6 months. Results Six months after varicocele repair 12 patients (52.2 %) were still azoospermic (Group 1) while 11 patients (47.8 %) reported ejaculated spermatozoa (Group 2) [sperm count: 1.3 × 10 6 /mL; 0.5 × 10 6 /mL—1.6 × 10 6 /mL (median 25th–75th centiles)]. Serum baseline FSH was lower in Group 2 compared to Group 1 ( p  = 0.012), while no differences between groups were revealed for all other clinical and laboratory parameters. ROC analysis indicated that baseline FSH level predicted the appearance of ejaculated spermatozoa after treatment [AUC = 0.811; 95 % Confidence Interval (CI) 0.6–0.9; p  = 0.0029]. A cut-off level of FSH
ISSN:1720-8386
1720-8386
DOI:10.1007/s40618-015-0259-x