Absence of an association between rubella vaccination and arthritis in underimmune postpartum women

In a double-blind historical cohort study, 485 underimmune women who received rubella vaccine post-partum during 1985–1990 and 493 controls matched for age, place of residence and date of delivery were queried by phone concerning joint complaints following the pregnancy in question. Those reporting...

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Bibliographic Details
Published in:Vaccine 1995, Vol.13 (16), p.1529-1532
Main Authors: Slater, Paul E., Ben-Zvi, Tirtsa, Fogel, Alice, Ehrenfeld, Michael, Ever-Hadani, Shai
Format: Article
Language:English
Subjects:
Adolescent
Adult
arthritis
Arthritis - chemically induced
Arthritis - epidemiology
Arthritis - etiology
Arthritis, Reactive - epidemiology
Arthritis, Reactive - etiology
Biological and medical sciences
Cohort Studies
Double-Blind Method
Evaluation Studies as Topic
Female
Fundamental and applied biological sciences. Psychology
Humans
Immunocompromised Host
Incidence
Microbiology
Postpartum Period - immunology
Pregnancy
Rubella - complications
Rubella - immunology
Rubella vaccination
Rubella Vaccine - adverse effects
rubella virus
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies
Virology
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Summary:In a double-blind historical cohort study, 485 underimmune women who received rubella vaccine post-partum during 1985–1990 and 493 controls matched for age, place of residence and date of delivery were queried by phone concerning joint complaints following the pregnancy in question. Those reporting joint symptoms were invited for a personal interview at which joint symptoms and dates of their occurrence were explored in detail. Nineteen women in the vaccinated group (3.9%) and 16 from the control group (3.2%) were judged to have had joint symptoms compatible with the study definition of arthritis. The difference was not statistically significant. Thus, we were unable to find evidence for an association between rubella vaccination of underimmune adult women vaccinated post-partum and the subsequent development of arthritis. Rubella vaccine should continue to be used to immunize susceptible adult women against rubella in order to further the goal of elimination of the congenital rubella syndrome.
ISSN:0264-410X
1873-2518
DOI:10.1016/0264-410X(95)00096-J