Accelerometer-measured sedentary time and cardiometabolic biomarkers: A systematic review

Abstract Objective We conducted a systematic review to investigate the cross-sectional and prospective associations of accelerometer-measured total sedentary time and breaks in sedentary time with individual cardiometabolic biomarkers in adults ≥ 18 years of age. Methods Ovid Medline, Embase, Web of...

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Bibliographic Details
Published in:Preventive medicine 2015-07, Vol.76, p.92-102
Main Authors: Brocklebank, Laura A, Falconer, Catherine L, Page, Angie S, Perry, Rachel, Cooper, Ashley R
Format: Article
Language:English
Subjects:
Accelerometer
Accelerometry
Biomarkers - blood
Blood Glucose - analysis
Breaks in sedentary time
Cardiometabolic risk factors
Cross-Sectional Studies
Diabetes Mellitus, Type 2 - prevention & control
Exercise - physiology
Female
Humans
Insulin Resistance - physiology
Internal Medicine
Male
Prospective Studies
Risk Factors
Sedentary Lifestyle
Sedentary time
Systematic review
Triglycerides - blood
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Summary:Abstract Objective We conducted a systematic review to investigate the cross-sectional and prospective associations of accelerometer-measured total sedentary time and breaks in sedentary time with individual cardiometabolic biomarkers in adults ≥ 18 years of age. Methods Ovid Medline, Embase, Web of Science and the Cochrane Library were searched for studies meeting the inclusion criteria. Due to inconsistencies in the measurement and analysis of sedentary time, data was synthesised and presented narratively rather than as a meta-analysis. Results Twenty-nine studies were included in the review; twenty-eight reported on total sedentary time and six on breaks in sedentary time. There was consistent evidence from cross-sectional data of an unfavourable association between total sedentary time and insulin sensitivity. There was also some evidence that total sedentary time was unfavourably associated with fasting insulin, insulin resistance and triglycerides. Furthermore, there was some evidence from cross-sectional data of a favourable association between breaks in sedentary time and triglycerides. Conclusion Total sedentary time was consistently shown to be associated with poorer insulin sensitivity, even after adjusting for time spent in physical activity. This finding supports the proposed association between sedentary time and the development of Type 2 diabetes and reinforces the need to identify interventions to reduce time spent sedentary.
ISSN:0091-7435
1096-0260
DOI:10.1016/j.ypmed.2015.04.013