Comparison of Automated Brain Volume Measures obtained with NeuroQuant® and FreeSurfer

ABSTRACT PURPOSE To examine intermethod reliabilities and differences between FreeSurfer and the FDA‐cleared congener, NeuroQuant®, both fully automated methods for structural brain MRI measurements. MATERIALS AND METHODS MRI scans from 20 normal control subjects, 20 Alzheimer's disease patient...

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Bibliographic Details
Published in:Journal of neuroimaging 2015-09, Vol.25 (5), p.721-727
Main Authors: Ochs, Alfred L., Ross, David E., Zannoni, Megan D., Abildskov, Tracy J., Bigler, Erin D.
Format: Article
Language:English
Subjects:
Aged
Algorithms
Alzheimer Disease - pathology
Alzheimer's disease
Automation
Brain - pathology
Brain morphometry
Female
freesurfer
Humans
Image Enhancement - methods
Image Interpretation, Computer-Assisted - methods
Imaging, Three-Dimensional - methods
Magnetic Resonance Imaging - methods
Male
Neuroimaging
neuroquant
Organ Size
pallidum
Pattern Recognition, Automated - methods
reliability
Reproducibility of Results
Sensitivity and Specificity
Software
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Summary:ABSTRACT PURPOSE To examine intermethod reliabilities and differences between FreeSurfer and the FDA‐cleared congener, NeuroQuant®, both fully automated methods for structural brain MRI measurements. MATERIALS AND METHODS MRI scans from 20 normal control subjects, 20 Alzheimer's disease patients, and 20 mild traumatically brain‐injured patients were analyzed with NeuroQuant® and with FreeSurfer. Intermethod reliability was evaluated. RESULTS Pairwise correlation coefficients, intraclass correlation coefficients, and effect size differences were computed. NeuroQuant® versus FreeSurfer measures showed excellent to good intermethod reliability for the 21 regions evaluated (r: .63 to .99/ICC: .62 to .99/ES: –.33 to 2.08) except for the pallidum (r/ICC/ES = .31/.29/–2.2) and cerebellar white matter (r/ICC/ES = .31/.31/.08). Volumes reported by NeuroQuant were generally larger than those reported by FreeSurfer with the whole brain parenchyma volume reported by NeuroQuant 6.50% larger than the volume reported by FreeSurfer. There was no systematic difference in results between the 3 subgroups. CONCLUSION NeuroQuant® and FreeSurfer showed good to excellent intermethod reliability in volumetric measurements for all brain regions examined with the only exceptions being the pallidum and cerebellar white matter. This finding was robust for normal individuals, patients with Alzheimer's disease, and patients with mild traumatic brain injury.
ISSN:1051-2284
1552-6569
DOI:10.1111/jon.12229