53BP1 suppresses epithelial–mesenchymal transition by downregulating ZEB1 through microRNA‐200b/429 in breast cancer

Epithelial–mesenchymal transition (EMT) is an important mechanism of cancer invasion and metastasis. Although p53 binding protein 1 (53BP1) has been implicated in several biological processes, its function in EMT of human cancers has not yet been reported. Here, we show that 53BP1 negatively regulat...

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Bibliographic Details
Published in:Cancer science 2015-08, Vol.106 (8), p.982-989
Main Authors: Kong, Xiangnan, Ding, Xia, Li, Xiaoyan, Gao, Sumei, Yang, Qifeng
Format: Article
Language:English
Subjects:
53BP1
Animals
Blotting, Western
breast cancer
Breast Neoplasms - genetics
Breast Neoplasms - pathology
Cell Line, Tumor
Cell Movement - genetics
Down-Regulation
Epithelial-Mesenchymal Transition - genetics
epithelial–mesenchymal transition
Female
Fluorescent Antibody Technique
Gene Expression Regulation, Neoplastic - genetics
Genes, Tumor Suppressor
Heterografts
Homeodomain Proteins - biosynthesis
Homeodomain Proteins - genetics
Humans
Immunohistochemistry
Intracellular Signaling Peptides and Proteins - genetics
Mice
microRNA
MicroRNAs - genetics
Original
Reverse Transcriptase Polymerase Chain Reaction
Transcription Factors - biosynthesis
Transcription Factors - genetics
Transfection
Tumor Suppressor p53-Binding Protein 1
ZEB1
Zinc Finger E-box-Binding Homeobox 1
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