Relationship Between Physical Frailty and Low-Grade Inflammation in Late-Life Depression

Objectives To determine whether physical frailty is associated with low‐grade inflammation in older adults with depression, because late‐life depression is associated with physical frailty and low‐grade inflammation. Design Baseline data of a cohort study. Setting Primary care and specialized mental...

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Bibliographic Details
Published in:Journal of the American Geriatrics Society (JAGS) 2015-08, Vol.63 (8), p.1652-1657
Main Authors: Arts, Matheus H.L., Collard, Rose M., Comijs, Hannie C., Naudé, Petrus J.W., Risselada, Roelof, Naarding, Paul, Oude Voshaar, Richard C.
Format: Article
Language:English
Subjects:
Acute-Phase Proteins
Aged
Biomarkers - blood
Body weight loss
C-reactive protein
C-Reactive Protein - metabolism
Depression - blood
Depression - complications
Depression - physiopathology
depressive disorder
Enzyme-Linked Immunosorbent Assay
Female
Frail Elderly
Frailty
Gait
Gelatinase
Genotype & phenotype
Geriatric psychology
Hand Strength - physiology
Humans
Inflammation
Inflammation - blood
Inflammation - complications
interleukin-6
Interleukin-6 - blood
Life Style
Lipocalin
Lipocalin-2
Lipocalins - blood
Male
Mental depression
Mental disorders
Middle Aged
Morbidity
Motor Activity - physiology
Nephelometry and Turbidimetry
neutrophil gelatinase-associated lipocalin
Phenotype
Phenotypes
Physical activity
Prognosis
Proto-Oncogene Proteins - blood
Reciprocity
Regression analysis
Self destructive behavior
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Summary:Objectives To determine whether physical frailty is associated with low‐grade inflammation in older adults with depression, because late‐life depression is associated with physical frailty and low‐grade inflammation. Design Baseline data of a cohort study. Setting Primary care and specialized mental health care. Participants Individuals aged 60 and older with depression according to Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, criteria (N = 366). Measurements The physical frailty phenotype, defined as three out of five criteria (weight loss, weakness, exhaustion, slowness, low physical activity level), and three inflammatory markers (C‐reactive protein (CRP), interleukin‐6 (IL‐6), and neutrophil gelatinase–associated lipocalin (NGAL)) were assessed. Results The physical frailty phenotype was not associated with inflammatory markers in linear regression models adjusted for sociodemographic characteristics, lifestyle characteristics, and somatic morbidity. Of the individual criteria, handgrip strength was associated with CRP (β = −0.21, P = .002) and IL‐6 (β = −0.25, P 
ISSN:0002-8614
1532-5415
DOI:10.1111/jgs.13528