Meta-analysis of dopamine receptor D1 rs4532 polymorphism and susceptibility to antipsychotic treatment response

Abstract Previous association results between dopamine D1 receptor (DRD1) rs4532 polymorphism and antipsychotic treatment response in schizophrenia and schizoaffective subjects have been conflicting. Thus, we have conducted a systematic review followed by a meta-analysis. Our results indicated no as...

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Bibliographic Details
Published in:Psychiatry research 2015-09, Vol.229 (1), p.586-588
Main Authors: de Matos, Luiza P.R, Santana, Cinthia V.N, Souza, Renan P
Format: Article
Language:English
Subjects:
Antipsychotic Agents - therapeutic use
Clozapine
Clozapine - therapeutic use
Female
Genetic Predisposition to Disease - epidemiology
Genetic Predisposition to Disease - genetics
Humans
Male
Pharmacogenetics
Pharmacogenomics
Polymorphism, Single Nucleotide - genetics
Psychiatry
Receptors, Dopamine D1 - genetics
Schizophrenia - drug therapy
Schizophrenia - epidemiology
Schizophrenia - genetics
Treatment Outcome
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Description
Summary:Abstract Previous association results between dopamine D1 receptor (DRD1) rs4532 polymorphism and antipsychotic treatment response in schizophrenia and schizoaffective subjects have been conflicting. Thus, we have conducted a systematic review followed by a meta-analysis. Our results indicated no association between DRD1 rs4532 polymorphism and overall antipsychotic response or clozapine monotherapy response.
ISSN:0165-1781
1872-7123
DOI:10.1016/j.psychres.2015.07.054