A comparison of the efficacy of artesunate plus sulfadoxine-pyrimethamine with that of sulfadoxine-pyrimethamine alone, in the treatment of uncomplicated, Plasmodium falciparum malaria in eastern Sudan

In an open, randomized, clinical trial, conducted in New Halfa, eastern Sudan, in September-October 2004, the efficacies and adverse effects of artesunate plus sulfadoxine-pyrimethamine (SP), in the treatment of uncomplicated, Plasmodium falciparum malaria, were compared with those of SP alone. Pati...

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Bibliographic Details
Published in:Annals of tropical medicine and parasitology 2005-07, Vol.99 (5), p.449-455
Main Authors: Adam, I., A-Elbasit, I. E., Idris, S. M., Malik, E. M., Elbashir, M. I.
Format: Article
Language:English
Subjects:
Adolescent
Antimalarials - adverse effects
Antimalarials - therapeutic use
Artemisinins - adverse effects
Artemisinins - therapeutic use
Biological and medical sciences
Child
Child, Preschool
Drug Combinations
Drug Therapy, Combination
Female
General aspects
Human protozoal diseases
Humans
Infectious diseases
Malaria
Malaria, Falciparum - drug therapy
Male
Medical sciences
Parasitemia - drug therapy
Parasitic diseases
Plasmodium falciparum
Protozoal diseases
Pyrimethamine - adverse effects
Pyrimethamine - therapeutic use
Recurrence
Sesquiterpenes - adverse effects
Sesquiterpenes - therapeutic use
Sudan
Sulfadoxine - adverse effects
Sulfadoxine - therapeutic use
Treatment Failure
Treatment Outcome
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Summary:In an open, randomized, clinical trial, conducted in New Halfa, eastern Sudan, in September-October 2004, the efficacies and adverse effects of artesunate plus sulfadoxine-pyrimethamine (SP), in the treatment of uncomplicated, Plasmodium falciparum malaria, were compared with those of SP alone. Patients were randomized to receive either artesunate (4 mg/kg. day) on days 0-2 plus SP (25 mg sulfadoxine/kg) on day 0 or the SP alone, and then followed-up for 28 days. Sixty patients completed follow-up. Compared with the 30 given artesunate plus SP (ASP), the 30 given SP alone were much more likely to be febrile (30% v. 3.3%; P=0.006) and parasitaemic (50% v. 6.7%; P
ISSN:0003-4983
1364-8594
DOI:10.1179/136485905X36299