Isofuranodiene: A neuritogenic compound isolated from wild celery (Smyrnium olusatrum L., Apiaceae)

[Display omitted] •Isofuranodiene is the major volatile constituent of the neglected vegetable Smyrnium olusatrum.•Isofuranodiene exerted neuritogenic effects on PC-12 cells.•Isofuranodiene neuritogenic action was synergistic to that of NGF. In the search for neuroactive compounds that mimic the ner...

Full description

Saved in:
Bibliographic Details
Published in:Food chemistry 2016-02, Vol.192, p.782-787
Main Authors: Mustafa, Ahmed M., Maggi, Filippo, Papa, Fabrizio, Kaya, Elif, Dikmen, Miris, Öztürk, Yusuf
Format: Article
Language:English
Subjects:
Animals
Apiaceae
Apium graveolens - chemistry
Cell Differentiation - drug effects
Cell Survival - drug effects
Furans - analysis
Furans - pharmacology
Image Processing, Computer-Assisted
Isofuranodiene
Nerve growth factor
Nerve Growth Factor - metabolism
Neurite outgrowth image analysis
Neuritogenic activity
Neuroprotective Agents
Oils, Volatile - analysis
PC-12 cells
PC12 Cells
Plant Extracts - analysis
Plant Extracts - pharmacology
Rats
Smyrnium olusatrum L
xCELLigence RTCA DP system
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:[Display omitted] •Isofuranodiene is the major volatile constituent of the neglected vegetable Smyrnium olusatrum.•Isofuranodiene exerted neuritogenic effects on PC-12 cells.•Isofuranodiene neuritogenic action was synergistic to that of NGF. In the search for neuroactive compounds that mimic the nerve growth factor (NGF) activity for the protection against neurodegenerative diseases, the potential medicinal values of foods and plants attracts intense interest. Isofuranodiene is the major constituent of the essential oil of wild celery (Smyrnium olusatrum L., Apiaceae). The cytotoxic effects of isofuranodiene towards rat neuronal PC-12 pheochromocytoma cells were determined by MTT assay, while the cell differentiation was evaluated with xCELLigence real time cell analysis system (RTCA DP), and the neuritogenic activity was assessed by neurite outgrowth image analysis. Isofuranodiene at concentrations of 25 and 12.5μM alone, or in combination with 50nM NGF, showed a marked stimulation of neuritogenesis, but it was more effective at 12.5μM with or without NGF. The present study reports the first evidence of the neuritogenic effects of isofuranodiene, which appears to be a promising neurotrophic and neuroprotective agent deserving further investigation.
ISSN:0308-8146
1873-7072
DOI:10.1016/j.foodchem.2015.07.079