Human Platelet Polymorphism can be a genetic marker associated with HIV/HCV coinfection

• Published in: Journal of medical virology 2015-10, Vol.87 (10), p.1677-1681
• Main Authors: Grotto, Rejane Maria Tommasini, Picelli, Natália, de Souza, Lenice do Rosário, Silva, Giovanni Faria, Ferrasi, Adriana Camargo, de Arruda Silveira, Liciana Vaz, Inês de Moura Campos Pardini, Maria
• Format: Article
• Language: English
• Subjects: Adult; Antigens, Human Platelet - genetics; Blood platelets; Coinfection - genetics; Female; Genetic Markers; Genotype; Genotype & phenotype; Hepatitis; Hepatitis C - complications; Hepatitis C - genetics; Hepatitis C virus; HIV; HIV Infections - complications; HIV Infections - genetics; HIV/HCV coinfection; Human immunodeficiency virus; human platelet polymorphism -1; human platelet polymorphism -3; human platelet polymorphism -5; Humans; Male; Middle Aged; Polymorphism; Polymorphism, Genetic; Real-Time Polymerase Chain Reaction; RNA, Viral - genetics; Sequence Analysis, DNA; Virology
• ISSN: 0146-6615; 1096-9071
• DOI: 10.1002/jmv.24233

To evaluate the associations of HPA polymorphisms ‐1, ‐3, and ‐5 with HIV/HCV coinfection were included in this study 60 HIV/HCV‐coinfected patients from the Sao Paulo State health service centers. Data reported by Verdichio‐Moraes et al. (2009: J. Med Virol 81:757–759) were used as the non‐infected and HCV monoinfected groups. Human Platelet Polymorphism genotyping was performed in 60 Patients co‐infected with HIV/HCV by PCR‐SSP or PCR‐RFLP. HIV subtyping and HCV genotyping was performed by RT‐PCR followed sequencing. The data analyses were performed using the χ2 test or Fisher's Exact Test and the logistic regression model. Patients coinfected with HIV/HCV presented HCV either genotype 1 (78.3%) or non‐1 (21.7%) and HIV either subtype B (85.0%) or non‐B (15%). The Human Platelet Polymorphism‐1a/1b genotype was more frequent (P